carlsborg

Cool. Could we train a "potential oncoprotein" classifier on Orthrus embeddings? IMO self serve diagnosis and detection is a far larger market than synthesis.

Opus is already severely crippled: asking it "whats your usage policy for biology" triggers a usage violation.

> "Earth has 4550 satellites in orbit"

Rapidly obsoleted information. SpaceX alone has > 7500 satellites in orbit. It added 2,300+ satellites in the one year period ending Jun 2025.

Also not to be confused with:

* Threonine: One of the 20 base amino acids, forms proteins. You need to get it from a food source.

I thought people were dosing themselves with a base amino acid. Duh. Theanine is an amino acid found in green tea, but not a base amino acid, ie doesn't form proteins. Can cross the blood-brain barrier and can certainly modulate brain function.

Not to be confused with:

* Thiamine: Vitamin B1, a molecule your body does not produce so you a get it from a food source. Needed for biochemical pathways that convert carbohydrates into energy. Not an amino acid.

* Thymine: One of the four nucleotide bases in DNA, pairs with Adenine. Synthesized in the body from the pyrimidine synthesis pathways

The great filter: light years of travel needed by detection probes.

This is critical, more people need to read this.

"Upstream Wayland basically fixed most of the technical things I complained about." in update linked right on top.

Anthropic blog has a nice distinction between LLM Workflows and Agents:

LLM Workflows: predefined code paths. Includes retrieval/tools/memory, routing based chatbots, orchestrator-worker, iterative evaluator etc

Agents: dynamically direct themselves. reasoning and planning, typically using tools based on env feedback in a loop.

From a biology perspective base amino acids (such as theanine) on their own are not generally major modulators of human function. You want to experiment with small molecules, something that binds with proteins such as enzymes which in turn modulate pathways and cell functions.

Binders need a energy configuration and 3 dimensional structures that "fits" into such proteins, and individual amino acids dont really cut it. Also the amino acids get rapidly used for protein construction so they dont stick around long.

PhDs in the subject can please correct me I am wrong here.

The official docs reference those numbers.

Its merged into CPython 3.13 but labeled as experimental.

Single threaded cpu bound workloads suffer in benchmarks (vs i/o workloads) till they put back the specializing adaptive interpreter (PEP 659) in 3.14. Docs say a 40% hit now, target is 10% at next release.

C extensions will have to be re-built and ported to support free threaded mode.

Some interesting and impactful bits of open source work for those with a c++ multithreading background.

Impressive.

The main lichess engine (lila, open source) is a single monolith program that's deployed on a single server. It serves ~5 million games per day. But there are a several other pieces too. They discuss the architecture here https://www.youtube.com/watch?v=crKNBSpO2_I

BTW consider donating if you use lichess.

Did you look at CDK8s?

Would make sense. Good fit.

Back in 2015, AMD was trading at $2.40 and Nvidia at about 50 cents (accounting for stock splits). 1000 USD invested then would be ~$70,000 and ~$256,000 respectively today.

Admirable level of honesty. Great signalling for culture.

If you ask ChatGPT to reply in the style of Arthur Whitney, you get amazingly concise summaries. Like a language verion of this code. I use that prompt often.

Would you trust the CryoEM structures more?

This company extracted ~$22 Billion in gross trading revenue from markets with quantitative trading strategies last year.

The Cyc project proposed the idea of software "assistants" : formally represented knowledge based on a shared ontology, reasoning systems that can draw on that knowledge, handle tasks and anticipate the need to perform them.[1]

The lead author on [1] is Kathy Panton who has no publications after that and zero internet presence as far as i can tell.

[1] Common Sense Reasoning – From Cyc to Intelligent Assistant https://iral.cs.umbc.edu/Pubs/FromCycToIntelligentAssistant-...

What do you use instead? We found the product and mobile app to be very well made - everything just works and fits in well together.

This company does ~2.2 Billion USD in revenue and Gross Profit of ~1.8 Billion USD on that. Mouth watering margins. A thing of beauty. Opex is high, but its mostly $1B on sales and marketing.

The play is probably going to be cut that marketing budget drasticly and piggy back on AdSense client base for growth. So job cuts would be forthcoming.

At this point the focus should be on making interop with python a first class feature.

This gentleman, Jean-Paul Clozel, exited to Johnson and Johnson for $30 Billion _cash_. Ex Roche, founded Actelion Pharmaceuticals with his wife in a rented lab and developed drugs for rare diseases.

I think the "Rachel" effect on global toddler vocabulary is deeply underestimated.

Pre 2008 crisis, that amount was equivalent to almost 120k USD and then just prior to Brexit it was about 90k in USD and today its about 75k US. So it used to be comfortable number.

Despite that, the UK is a fine country i will add. Things just work, cities are functional and livable, schools are free, and the NHS carries its weight - it is overloaded but if they introduce a small fee for GP visits and keep the big things like surgical interventions and cancer treatment free, it would maybe balance out its budget.

Amazing perspective. Are any of the talks online?

Founder profile: started out as a rates trader at Goldman, and then founded RabbitMQ and sold it to VMware.

King.