chispamed

I have gone serverless for a Vue frontend app I deliver with Cloudflare Workers Sites and with a DigitalOcean S3 Space serving all images. However I'm still very reluctant to use Google Cloud Computing or any similar Azure/AWS solutions for its backend because it just seems pretty expensive to me.

I can get a vServer with 48 Gb RAM, 10 vCPUs and a 800 SSD with a 1000 Mbit/s connection and unlimited traffic for 20€ a month and run my MariaDB and Redis database on the same machine as my other containers.

Even if the vServer only runs at 25% on average the same performance with GC would cost me 150€ for the CPU, 77€ for the RAM (with free tier already included) and that is still not accounting for the traffic. And I would have to host the MariaDB instance elsewhere (which adds latency). And Google Cloud has very few data centers in Europe so it'd not even be near my main market.

In this case Google Cloud Run (with worse performance) would cost me like 15x more than running a vServer. That's not a price I'm willing to pay to go completely serverless or to avoid downtime at all costs. Or am I missing something?

Vue-cli at least has a very neat feature; if you build with the —-modern flag it will create two versions of your scripts, one with modern syntax, smaller and faster for modern browsers and another legacy version for older browsers you have to support. It then uses the nomodule html attribute to automatically load the version your browser needs. This also has the nice effect of saving you bandwidth costs.

I noticed that wires that are not perfectly round (they’re kinda rectangular with one very thin and one wider side) don’t tangle as much as the round ones and I’ve seen a lot of those in recent years. So form might be a factor as well.

In my experience it’s easier to manage permissions on iOS and it’s easier to see which apps used them. So while app vendors probably try to include the same spying software on both platforms I’m able to restrict their data access in a more straightforward way on iOS.

Might I ask what reason your doctor gave? To my current knowledge there's no blood LDL too low / blood LDL is not an adequate tool to judge any deficiencies.

I'm a last year med student who eats plant-based himself and my physician was very pleased with my very low cholesterol levels.

Blood cholesterol is not 100% necessary to provide your cells with colesterol as they can produce their own. In fact blood cholesterol medication exploits the fact that cells produce a good chunk of the cholesterol they need themselves. PSCK9-inhibitors prolong the half-life of LDL-receptors in the cell membrane and thereby increase the endocystosis of LDL particles which in change leads to SREBP1-mediated reduction of the cell's own cholesterol production. If virtually all blood cholesterol was taken up you would have very low levels of blood LDL but that would not translate to a deficiency at a celular level.

Here's a NEJM published study where blood LDL was reduced to a median of < 30 mg/dl and in some indiviudals even to < 10mg/dl with a positive outcome, way beyond current targets: https://www.nejm.org/doi/10.1056/NEJMoa1615664

Here is another study by the same author concluding that starting lipid medication at levels as low as 63 mg/dl might have positive outcomes: https://www.ncbi.nlm.nih.gov/m/pubmed/30073316/

On a side note, from what I've read I thought nuts did not lead to a higher cholesterol but if anyone has a study proving me wrong I'd be glad to read it as I haven't spend much time researching the effect of nuts.

In Germany you can also get paid to donate blood or plasma. So this definitely happens in Europe as well. However the pay is not that high, it’s basically just a small compensation for your lost time and nutrients.

I disagree, image compression is still highly relevant and will stay relevant for a long time. It’s not about hosting costs and hosting bandwidth, it’s about user bandwidth.

I frequently travel between countries by train and bus and when outside cities it’s almost impossible to get any non-optimized page to load. And this doesn’t even only extend to the time spent inside the train. Depending on the country (all developed) and which phone operator my phone decides to switch to, I have slow mobile internet about half of the time. This is also one of the reasons why I prefer to read HN over other sites: HN loads, others don’t.

Most images on a modern website don’t really contribute anything substantial but are merely decorative. Image quality loss should therefore not be a problem for ~90% of images.