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davi

3,486 karma · joined April 17, 2008

large scale electron microscopy of brain wiring

https://scholar.google.com/citations?user=UYNRtmkAAAAJ&hl=en&oi=ao

submissionscomments
davi··on Poll: HNSearch Contest Voting
This is great, it let me quickly relocate mechanical_fish's classic "gone to the zoo" metaphor. Probably still the all-time best post I've read on HN: http://bitovod.com/hn/best-of?limit=100&username=mechani...
davi··on Positive Black Swans: How to fund research so that it generates great ideas
Interesting to see the Howard Hughes Medical Institute mention. I'm a Fellow at the Janelia Farm Research Campus of HHMI. I get a big budget, two people in my group, the ability to use massive internal resources (electrical and mechanical engineers, software developers, histology, etc.), no teaching requirements, no administrative requirements, and a 5 year contract.

I'm swinging for the fences, no point in doing otherwise; this is my shot.

If anybody is curious: http://www.hhmi.org/research/fellows/bock.html

Browse big data: http://openconnectomeproject.org/catmaid/?pid=4&zp=0&...

Papers: http://reid.med.harvard.edu/pdf/Bock-Lee-etal-Reid-2011-Natu..., http://reid.med.harvard.edu/pdf/Bock-Lee-etal-Reid-2011-Natu...

And (last but not least) I am hiring: http://news.ycombinator.com/item?id=2504657

davi··on Bill Gates says he advocated Skype takeover
My take is he's uncomfortable with the deal and was likely not fully behind it.

Agreed it's distancing language but my guess is that he doesn't want to undercut Ballmer's authority.

davi··on Ask HN: Who is Hiring? (May 2011)
Ashburn, VA - Brain wiring diagram extraction

I'm hiring a software developer for my group at Janelia Farm Research Campus, in Ashburn, VA. The goal will be to develop workflow for extracting wiring diagrams of neuronal circuits from large-scale serial electron microscopy of brain tissue (10 TB+ image volumes). You can read about what I'm doing at http://www.hhmi.org/research/fellows/bock.html, and browse data at http://bit.ly/ga3Cfk. A detailed writeup of the approach was published last month in an article at Nature.

I think the ideal candidate could come from a variety of backgrounds -- someone who had previously written or contributed significantly to the development of a game engine could be good, for example. Looking for strong quantitative chops, creativity, and a willingness to do some plumbing in order to make an elegant solution.

davi··on Poll: Display points on comments?
I immediately liked the change. I realize now that in addition to evaluating the comments I was reading, I was also evaluating the readership's collective response to the comments. It makes for better reading to only evaluate one thing at a time.
davi··on Are Biology PhD students the most miserable?
A key problem is that the ratio of trainees (graduate students) to tenure track positions is way out of whack. It's a pyramid. I've made this point here in the past, with estimates of the numbers involved: http://news.ycombinator.com/item?id=470181
davi··on Ask HN: How to stave off decline of HN?
Delete humorous one-liners vigorously, especially ones that get lots of upvotes.

Lots of other good suggestions in this thread but I don't see this one.

I hope you can turn it around, I've gotten a lot of value from this site.

davi··on Ask HN: Who is Hiring? (April 2011)
I'm hiring a software developer for my group at Janelia Farm Research Campus, in Ashburn, VA. The goal will be to develop workflow for extracting wiring diagrams of neuronal circuits from large-scale serial electron microscopy of brain tissue. You can read about what I'm doing at http://www.hhmi.org/research/fellows/bock.html, and browse data at http://bit.ly/ga3Cfk. A detailed writeup of the approach was published a few weeks ago in an article at Nature.

I think the ideal candidate could come from a variety of backgrounds -- someone who had previously written or contributed significantly to the development of a game engine could be good, for example. Looking for strong quantitative chops, creativity, and a willingness to do some plumbing in order to make an elegant solution.

davi··on Wife Said No, Apple Said Yes
because jokes are now accepted on HN

and S/N for jokes is frequently low

and jokes are frequently divisive

and lots of people will give a quick upvote to something that gives them a reward for reading (i.e. makes them laugh)

and evaporative cooling

and yadda yadda yadda

davi··on Microsoft’s Effort to Build Apps and Reward Engineers
Thanks for writing up the PR process. Interesting, and potentially useful in the future.
davi··on Annotatr - scientific paper commenting done right
quick wishlist:

- interactive refinement of results as I type

- ability to restrict results to only papers that have been commented upon

- ability to restrict visibility of my comments to friends/colleagues

- ability to get notified if a particular abstract gets a threshold number of comments

As it stands, this is not a minimum viable product I will return to (though perhaps it would be if everyone else in my field used it). Nice try though, hopefully it will improve with iteration.

davi··on Langton's ant
Interned with Langton at SFI in summer of 1997. Great experience.
davi··on What if Flickr fails?
Pro users want access to a social network that has gotten huge because it's free. The pro users are nervous because free=fragile.

This brings to mind Fred Wilson's recent call for content shifting tools (http://www.avc.com/a_vc/2011/01/content-shifting.html, http://news.ycombinator.com/item?id=2085455).

davi··on Poll: Does the amount of time that you spend on HN hurt your productivity?
The only time it's a productivity hit to me is when I'm procrastinating anyway. I wouldn't worry about that. Focus on making the conversation as interesting as you can.
davi··on In Defense Of The PhD
Thanks very much for the well wishes you guys. I am very much looking forward to that sense of relief. In the coming week or two I will probably post a 'Show HN' of my project (wiring diagrams of neuronal connectivity).
davi··on In Defense Of The PhD
As it happens, I'm defending my dissertation tomorrow (neuroscience, U.S.) and this post pretty well sums up my sentiment.

I particularly agree with the ending:

    Oh you’re saying I’m a dreamer, and that simply never 
    happens? Well what about those thousands of internet 
    start-up companies? They waste their time as well, trying 
    to become another Facebook or another Google. Yet they 
    still do it, because it’s their dream to pursue.

    And so is academic career ours.
I think there are two modes one can do research in: one is a conservative, do-what-you're-told kind of incrementalism; another is higher risk, swing-for-the-fences, and entrepreneurial. I think there is a similarity between doing research in the latter mode and a technology startup, which is why I got sucked into Hacker News when it was still called Startup News. Nearly everybody on it was a maker, swinging for the fences. I felt a lot of affinity for the attitude if not the methods.

Anyway, enough HN procrastination, I need to practice my talk!

davi··on Gaming like it’s 1979
Interesting how much money there is to be made mining the disposable incomes of adults nostalgic for the pleasures of childhood.
davi··on Paul Buchheit: Four Reasons Google is still Awesome
Nearly orthogonally great answers from both of you, thanks.
davi··on Paul Buchheit: Four Reasons Google is still Awesome
This is really interesting: certain kinds of features and projects suck until they're good. A steeply sloped sigmoid of suckage.

Why did the people working on Instant persevere despite their coworkers' reactions? Was it because they had a clear end-vision of awesomeness, and they knew they just hadn't implemented to that point yet? Or was it more intuitive, a sense that there was awesomeness somewhere in parameter space, and that they could get there with continued iteration?

davi··on A Globe, Clothing Itself with a Brain (1995)
A strange eddy in the history of ideas.
davi··on [dead]
Don't feed it. Flag it. http://ycombinator.com/newsguidelines.html
davi··on Scientists find first evidence that many universes exist
googolplex; the Googleplex is a place :)

(Can't resist pedantry in this case; my grandfather taught me what a googol and a googolplex are way back in the dark ages and I have some affection for the terms)

davi··on Nano Watch Kit Near $1M on Kickstarter
That's interesting. At what quantity do they stop laughing?
davi··on How Google sets goals and measures success
Would've been much more interesting had some concrete examples been given. Anybody here know of any?
davi··on Yahoo is Shutting Down Del.icio.us
It happened to me the first time I tried to look at pinboard today. I'm on a satellite modem out in the middle of nowhere -- maybe a latency bug? Problem was gone when I tried a little later.
davi··on Launching Posterous Groups: Smart email lists made easy
What does she do on the Apple website? I've never thought of that as a 'destination' site on the web, but maybe I'm missing something. Movie trailers?
davi··on [dead]
Classic example of bad popular science writing. Linkbait title. What is effect size? What was sample size?

I wonder if the HN guidelines could use a line or two on criteria to use when deciding whether or not to submit a science story.

davi··on The Present and The Future (continued)
As myspace has shown, when platforms stagnate they can easily fall apart and the decline can be fast and devastating

This gave me an image of a large mass of pack ice floating on polar seas -- it occupies a vast area, you don't want to mess with it, but when conditions turn, the whole thing can very quickly break apart and dissolve. (http://www.igsoc.org/annals/44/a44a057.pdf)

davi··on Qantas QF32 flight from the cockpit (dealing with exploded engine)
Yeah, bad software is the point Philip Greenspun makes about the incident: http://blogs.law.harvard.edu/philg/2010/12/11/airbus-a380-en...
davi··on Show HN: Flattehn: A Chrome extension to hide points / users until you've voted
Why do we each have a name? On a website, it is so readers can associate what a commenter is saying to what that person has said before. Any community where people are going to encounter each other more than once has a use for names.

Here, look, patio11 just said the following: "Trust me on this: no. I used to have ABingo [yadda yadda]" [1]. Because it's patio11, I do trust him more, at least on this topic. And when he mentions ABingo, yeah, that's right, he has an A/B testing package he made for himself, that he opened sourced to people.

When someone I know is a maker talks about the domain in which they make things, they have more credibility to me. This is not celebrity worship (I have my own gig, thanks), it's just paying more attention to the people I find interesting.

Hiding names and points with a Chrome extension is a cool hack, but there's no way I'd ever want to use it myself.

[1] http://news.ycombinator.com/item?id=1996587

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