HNHacker News
TopNewBestAskShowJobs

desine

885 karma · joined May 24, 2019

submissionscomments
desine··on Pfizer’s Covid-19 Pill is 89% Effective in Phase 2/3 Study
>The reproducibility crisis is real and affects more than "some studies in some areas".

>"Peer review" rarely means more than "JSTOR search for something that supports my claim, quick skim for obvious errors, cite and publish"

>"Science" is only "accurate by definition" when it's done correctly. Buying scientists is cheaper than buying politicians, in practice.

desine··on Pfizer’s Covid-19 Pill is 89% Effective in Phase 2/3 Study
>Good luck! I look forward to your references to peer-reviewed, reproduced, double-blind studies upending decades of well established medical science.

Why is my burden of proof higher than yours? I at least linked one study in my sibling comment.

I haven't seen that from anyone, studying anything, in years. Around 2018 there were actually a ton of articles and discussions right here on HN about the reproducibility problem in science, and that there's no funding for reproducing studies anymore. Everything is just cite and move on. We were actually making significant progress in reforming our ideas of science, and the effects that scientific funding sources have on our knowledge, as a species (hint if it's not profitable we probably aren't studying it).

That all got thrown by the wayside as "trust the science" became the political rallying cry of half the population over the last year.

desine··on Pfizer’s Covid-19 Pill is 89% Effective in Phase 2/3 Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
desine··on Wingman for Haskell
At its heart stuff like this is no different than the jumps from punchcards you asm to c to python. You still need someone to solidify ideas into processes. The change is that the building blocks themselves become more complex.
desine··on Omicron variant more resistant to vaccine but causes less severe Covid: study
It's not because of mask mandates, it's because every politician is invested in pfizer and moderna, it's because pharma has massive lobbying power, and because pharma companies make up much of the advertising revenue of the news networks in the USA
desine··on Fredrik Lundh has died
You're not alone in that sequence. I think a few of us here saw "effbot" in that email and felt our minds simultaneously trace back where we heard it as our heart sank. He was a big python contributor, it seems, but I wonder if he realizes how much that little guide shaped the internal tooling of many major companies.
desine··on Space-shooter.c: cross-platform, top-down 2D space shooter written in C
Oh wow, it's all done using no 3rd party libraries too. Gonna bookmark this just to browse through later
desine··on Space-shooter.c: cross-platform, top-down 2D space shooter written in C
I think you're missing the point.
desine··on The CIA and the Media (1977)
Gary Webb showed journalists what their choices were, so if the CIA wants media influence, they get media influence.

edit: Also Michael Hastings, according to some. Webb was pretty blatant.

desine··on Ask HN: What are your 2022 predictions?
Employer mandate, non-governmental :-/
desine··on Ask HN: What are your 2022 predictions?
I lost mine for the same reason last month. USA. Stay strong, friend.
desine··on The Gold Standard and the Great Depression (1997)
>Even when the US had the gold standard, the US never had gold reserves that matched the dollars in circulation.

The US Dollar is/was originally defined as a measurement of silver, and based upon the Spanish Real - the same coin you hear in piratey accents as a "piece of eight" because it was usually cut into 8 pieces to make change. The US absolutely had metal to back every dollar in existence for about 100 years, though it wasn't gold. The real "gold standard" era was a stopover/band-aid effect of the growing disparity in value due to bimetallism, and came into effect after "The Crime of 1873".

desine··on The median voter is a 50-something white person who didn't go to college
The tradesmen likely know more about the logistical structure of a functioning society than most STEM employees, who too often live in ivory towers.

The restaurant staff often know more about human nature and behavior than the Psychiatrist who’s been trained to see all our flaws as chemical imbalances to be fixed.

Comments like yours are increasing the divide in this country, and are deeply problematic.

desine··on Six more zeros are to be removed from Venezuelan currency
I don’t know but my other comment about a certain hard asset I save in got a couple downvotes. I chalk it up to ignorance being bliss. Nobody wants to think about how easily they can lose it all
desine··on Six more zeros are to be removed from Venezuelan currency
Your highest level reply did not imply you were willing to consider socialism as a factor. Socialism is a very large factor in this. Not in principle, but in practice. Is it possible for a fair, balanced, stable form of socialism to be designed? Possibly, I don't know. Can a group of greedy, selfish, arrogant Great Apes manage it? Absolutely not.
desine··on Six more zeros are to be removed from Venezuelan currency
Turns out there's a cost to guaranteeing a certain quality of life, without requiring the productivity that was previously needed to secure it. Capitalism has its faults, but for the day to day management of a population, rewarding those who produce goods is a pretty logical baseline for economics
desine··on Six more zeros are to be removed from Venezuelan currency
While comparatively stable, the US Dollar is able to fall to the same faults that many other currencies have in history.

There's only one form of money that's retained value for over 6000 years of human civilizatoin.

desine··on Six more zeros are to be removed from Venezuelan currency
A sad reality is how true this is. Anyone who had built up savings 10+ years ago was already completely wiped out. The situation will not significantly change with this adjustment. The day to day for the common citizen of Venezuela is the same: work as much as you can, and immediately convert your money into tangibles: food, sundries, tools if one can be lucky enough to afford them. These things will continue to increase in cost, wages will continue to increase at comparable rates. It's a trap where one has no choice but to continue producing and consuming, and the money is nothing more than a temporary stopover.
desine··on GM tells some Bolt owners to park 50 feet away from other cars
To be fair this is the norm for pretty much any rechargeable electronic device. Lithium chemistries in particular are sensitive to damage from over discharging. "5% battery remaining on the display" is pretty much never "5% of available energy available"
desine··on Anonymous Hacks Epik
If you truly believe in freedom of speech, it makes sense to support companies who enable those ideals. I'm not familiar enough with the company/drama/story here, but if Epik does not do anything "problematic" other than allow "problematic" speech, then I would consider them. A certain quote often mis-attributed to Voltaire comes to mind [0]. It appears they do have some lines drawn in the sand for free speech, they cancelled service for 8chan.

[0] : https://en.wikipedia.org/wiki/Evelyn_Beatrice_Hall

desine··on As a virologist I’m shocked my work has been hijacked by anti-vaxxers
The proteins generated by the mRNA vaccines are shown to spread throughout the body, compared to the virus, which is mostly respitory and vascular.
desine··on As a virologist I’m shocked my work has been hijacked by anti-vaxxers
There have never been mRNA vaccines widely distributed
desine··on As a virologist I’m shocked my work has been hijacked by anti-vaxxers
Telling people their concerns are not valid also does not help
desine··on Ask HN: Is your company making vaccination mandatory?
Not yet, but our clients are discussing it, which would trickle down to us. We're already short engineers and I'm certain we would lose a few more, which would put them both in a tight spot.
desine··on Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
And I assume that you consider all the available variations as "well tested". Nice to hear that any personal concerns I have are not valid, and that you don't even need to read them to know that. Sad to see so many websites where discussions were once welcomed turned into echo chambers. Or perhaps I'm just one of those uneducated people who shouldn't even be on HN
desine··on Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
So there's no possible valid logic for not wanting an mRNA vaccine. It's all completely "delusion" stemming from propaganda? Anyone who does not have complete faith at this point is in the wrong?

Am I understanding you correctly?

desine··on Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
> First, vaccines prevent infection in the first place so the virus never has a chance to replicate and mutate

Ideally, yes, but in practice people still tend to develop a viral load, their immune system kicks in faster, and the result is a very brief infection.

>Second, there isn't anything about vaccine acquired immunity thats different from infection acquired immunity

This is not true with the mRNA vaccines.

desine··on Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate
Out of curiosity, if you're onboard with previous typical vaccination, but hesitant to jump on board with mRNA treatments, what are you? Does that now fall under "anti-vax" in internet lingo? Is wise to group everyone under one umbrella term?
desine··on OnlyFans drops planned porn ban
Why do you think they would be cheap? Many of the relevant chips have been out of production for decades. Sure you can emulate a lot on a logic device like an FPGA, but those are still expensive compared to a microprocessor, and your engineering costs will go up. Then you’re facing stiff competition- a vintage gamers ideal is exact hardware. Any sort of emulation will have slight quirks- timing changes, mildly perceptible audio frequency shifts, etc. if your product isn’t an exact match for the hardware, it’s competing with the hundreds of ARM based emulation oriented systems that popped up after the RetroPi concept took off. And for what, a few thousands units of sales? Most people fall into “fine with emulation + ROM”. A select few stick with vintage hardware, which is not expensive. The market for “very close to original hardware but not quite” is a hard sell.
desine··on Benefits of Not Using an IDE
I would never use power tools on my motorcycle or car. On threading, nuts/bolts/screws should always be torqued gently into spec. On unthreading, I prefer to feel if there's significant resistance, warranting a cleaning/deoxidization of the part.

Predrilling a screw hole in some hard wood? Yeah I don't need to feel anything except the power of lithium cells dumping electricity into torque.

← PreviousPage 2 of 9Next →