dm319

This isn't CAR-T, which is a chimeric antigen receptor (antibody) grafted onto a T cell. This is a T cell with an edited TCR receptor. This is quite different and comes under the 'adoptive TIL' category of treatments. It allows targeting of antigens not displayed on the cell surface. Every cell has to process their protein through a proteasome and present those peptides on the cell surface, which is where the advantage of this type of treatment comes in. In CAR-T we target a surface protein, and there's nothing to stop the cancer removing that protein from the cell surface.

Anyone know how this compares/fits with pure data?

Is there another numerical computing language that compiles?

That's really interesting, thank you for the perspective. I'm amazed so many long in the tooth vim/nvim have moved over!

I do think the movement could be better arranged in nvim/vim - but that's really just an issue of remapping keys I guess. hjkl are in a great place, the equivalent of home/end/pageup/down are odd and not ergonomic.

I compiled helix on a 1Ghz single core processor, and it runs incredibly fast on that. Very impressive.

I'm a long time user of vim/nvim and have learnt so many great techniques from "practical vim". Helix looks good, and the speed is impressive.

It does seem very code-centric though, movements seem based with this in mind. I also find it inconsistent that some movements cannot be combined with actions but others can.

Having said that, there are certainly some ways that vim could be reimagined. I find beginning and end of line movements awkwardly placed by default, as is moving up and down by half and whole pages.

I have a feeling that movement-action paradigm as opposed to action-movement paradigm of vim will have some tradeoffs with visualisation being a plus, and more advanced repetitions bring a negative, but I haven't totally thought this through.

Don't bother with a bike helmet! The only safety you need on your bike is the safety of your open carry firearm. When a careless driver pulls out of a side road and takes you out, you can both make them regret their decision and pay for your neurosurgery with a gun.

/s (sadly needed)

The Aeropress is a great device. I have a few brewing methods (V60, kalita wave, french press), but the aeropress is the most consistent, and as a bonus, is so easy to clean up too.

PS Good to hear about your project, sounds like a great aspiration and could help so many.

The article mentions that the Wii U had gamecube compatibility. I wonder how that was achieved? And I'm guessing it can't take the small optical disks of the gamecube.

The number of people who say 'I thought the Wii U was a handheld?', made me realise how badly they messed up. Home console buyers didn't realise it was a console. Handheld buyers realised quickly it wasn't a handheld.

If you put the Switch and the DS alongside it, you can see where they were coming from / going to.

Yes, really innovative use of the gamepad for ZombiU gave the game a properly scary aspect when checking in bags and boxes, and nervously looking up at the screen as you're doing it.

Debian is a pain! I just tried installing it on a laptop. During installation it points out it can't find a wifi driver and do I have it to hand? I didn't and I don't know where to find it. It says I can use ethernet, but the ethernet wasn't close to me at the time and laptop's battery was shot so I couldn't move. I proceed without internet. I google how to install non-free firmware after the fact, and find that there is an app in the repository. Once the install is done, I shut it down and move it to a room with ethernet. We boot up, plug it in and get internet! But for some reason I am not attached to any software repositories apart from those on an install CD/DVD. I don't know what has happened, but I assume that my lack of internet during install meant I don't have apt sources properly configured. I considered googling how to add these, but instead, I said goodbye to the early 2000s gnome 2 theme, shut it down and tried another debian-derived distro that has all the advantages of debian, a beautiful modern theme, and I don't spend hours googling things I don't know.

I think this is a key point - the training set is very important, because biases, over-curation, or wrong contexts will mean the model may perform very poorly for particular scenarios or demographics.

I can't find the reference now of a radiology AI system which had a good diagnosis rate of finding a pneumothorax on a chest x ray (air in the lining of the lung). This can be quite a serious condition, but is easy to miss. Turns out that the training set had a lot of 'treated' pneumothorax. The outcome was correct - they did indeed have a pneumothorax, but they also had a chest drain in, which was helping the prediction.

Similar to asking what the demographic of training set is, is what the recorded outcome was. How was the diagnosis made. There is often no 'gold standard' of diagnosis, and some are made with varying degrees of confidence. Even a post-mortem can't find everything...

My experience of chatting with an internet chat-bot when trying to get some help with a product gives me little confidence we are close here.

Edit: wording

As someone who works in healthcare, so much of what I read about AI makes me think that the people who are enthusiastic about healthcare AI don't have much experience doing it.

The scenarios rarely seem to fit with what I'm actually practicing. Most of medicine is boring, it is largely routine, and if we don't know what's going on, it's because we're not the right person to be managing the patient. Most of my time is spent talking to people - patients, colleagues, family. I explain the diagnosis, I talk about the plan, I am getting ideas of what the patient wants and values, and then actioning it. I spend very little of my time like Dr House pondering what the next most important test to perform is for a patient who is confounding us.

I know exactly what you mean. I saw it with a £40 amazon telescope.

You know that weird feeling when you, for whatever reason, take another route from somewhere you know well, find you've arrived at an unusual end of another place you know well. The moment of connection, realisation that these two places are linked in this way.

I felt that, but on a huge level seeing Saturn's rings for the first time. For years outerspace, without me realising, occupied a place in my encyclopedias, books, internet images from NASA. Maybe subconscious me didn't really 'believe' it was actually just above my head this whole time.

The comments are always a bit contrary to the topic here. I've used ubuntu since 2009, and I am still very much a fan. My preference is for ubuntuMATE, and I'll confess I'm not that keen on snaps, but overall, it's great to have an amazing free operating system to use like this.

I use a Linux laptop with my favourite applications (vim, vim-wiki, Firefox, pass). I don't try to integrate across devices, I just take it around with me.

I got an Amiga A1200 as a kid at Christmas. The first one was a dud, so slightly disappointed. But my dad came home with a replacement from Dixons a couple days later. I didn't have high hopes of it doing anything, but we put a disk in and powered it up. I distinctly remember that moment the a strange synth pitch bending sound started playing, causing mild alarm, followed by this parallel scrolling scene [1]. There were a few of us there, our collective jaws dropped.

I spent many years after that dabbling with electronic painting on Deluxe Paint IV, which had a terrific balance between being fun for someone who had no clue, but also opened up so many advanced features if you dug a bit (animation, morphing, colour cycling, brushes, gradient fills), and I've struggled to find something similarly joyous for my kids. I learnt to make music on Octamed. And I have so many fond memories of all the games I played; the little worlds we created in our heads where computer characters existed.

Partly as a result, I have enjoyed playing computer games with my kids. I join in with them playing Zelda BOTW, and minecraft. I know that they will look back fondly on these imaginary worlds. However, I do wish I could get them more interested in the creative side of digital art. Maybe that will come later.

[1] https://www.youtube.com/watch?v=wdkhNi3RwUY

Add to that the vagueness of where the road ends and field/bank begins for many country roads.

I was in my second year of University and really needed a computer for my studies. My last machine had been an Amiga A1200, which I adored, but sadly was going to be too much work to get it into a useful state for studies. I bought my first PC - a Thinkpad T40 brand new. I was intrigued about the 'embedded securiy subsystem'. Back then things like this seemed cool and exciting to me. I set a password, excited that I could lock the system at such low level. It rebooted, I typed in the password, and it beeped at me an error. I typed it in again, and got another beep. I remember starting to sweat. Third time it worked. I must have typo'd something, so I immediately unset it and never did that again.

The Thinkpads retain good feel until the *30 series. They are 'chiclet', but having had a T40, T60p and X230, I am confident the X230 has the best feel and same travel. The depth of travel continued to the T450 and T450s, but the feel dropped off by then.

There is a gaming laptop with mechanical keys also.

There are too many people here who care more about delivering what they think is a clever counterpoint, while being proud of denying the existence of 'soft' forms of intelligence, empathy and morality.

There are several VR 3D Super Mario Bros adaptations which are easily found on google. But of course they have to take liberties in the Z plane.

Not in neovim anymore!

EDIT: Oops, you weren't replying to my 'dd' question. Sorry ignore me. Though if you know the equivalent of 'dd' in helix I'd like to know...

That makes a lot of sense. I don't like to characterise 'left' and 'right' as being more or less factual, but we've experience a distorted massaging of facts in my country from papers like the Daily Telegraph. There are a bunch of people who like to say things to persuade people of their point of view, and are upset when the evidence doesn't agree with them. I can see something like wikipedia making these people upset.

There are people who want it to fail, people who like to make untruthy statements.

Be wary of the cogs grinding in the background that can lead to an article like this hitting popularity.

There are many people with axes to grind with wikipedia - disagreements with the way certain topics are represented, and the way wikipedia has become a huge resource for information and news is not good news for everyone.

I spend way more money on entertainment being piped into my TV, or deliveries happening a day quicker than I do on a website I use several times a day.

Thanks, that's helpful.

I get it - so 't' is 'to' and enter is new line. Makes sense.

The menu under `[` looks good, but very code-focused and lacking sentences.

EDIT: I am finding it a bit weird to have 'go to's as different to movements. There isn't a distinction in vim, which is useful. I'm learning that 'ge' will take me to the end of file, but I can't do 'ged' to delete to there.

There have been generational changes which may explain the different attitudes. I am an older millenial, and was brought up on the idea of putting in extra to learn and develop my career. I followed the leads of my boomer seniors.

But I don't get the benefits they did. For my line of work (not IT), I work harder, I am paid less, I pay more on my mortgage, I live in smaller, less salubrious places than they do, I will get a smaller pension, I need my wife to continue working to pay for everything. My children will have less opportunities, their university education won't be funded.

I think my specific generation were the suckers, and I can't, hand-on-heart, tell the Gen Z juniors that if they just work their arses off, they will be given some career with these kind of rewards.

Yet another aspect is that the boomers were largely male, with wives and kids who hardly saw them. This is far less tolerable these days. For every keen junior who committed 200%, there was an unhappy partner doing all the housework and bringing up the kids.