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ijustlovemath

1,328 karma · joined September 22, 2020

really, I do.

for work/pancreas related inquiries: imt < a > idealmedtech.com

Put "HN32" in the subject to escape my spam filter

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ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
None have been approved for hospital use as of yet, which is the next frontier.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
Ah yes, I see what you mean! Ketones are not inherently bad, just the accumulation of them w.r.t having diabetes. Should have made that more clear.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
Lactate's available in the internal engineering data of these sensors, just not something that anyone has wanted to spend the time or money to qualify with the FDA. It essentially comes "for free" due to the chemical reaction the sensor uses.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
It can happen in people with uncontrolled T2D as well. My cofounder is a pediatric ICU doctor who has treated hundreds of DKA patients.

Also there wasn't really a relationship of the keto diet to the rest of my post, just using it to contextualize a technical term with one that might be more familiar.

ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
Cardiac surgery, burn units, ICU, neuro come to mind. All have been studied to show mortality and complications improvements with AGC, but unfortunately the commercial technology has not materialized yet.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
There are 6 month implantable CGMs, they're just quite expensive.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
Lactate actually comes for free with blood glucose when you measure it with a chemical sensor, it's just not something that's usually asked for. I definitely think it would be considered a form of doping to use it in competition, but I think recovery is where it would make more impact anyways. You also wouldn't want to use it before a race, as you'd run the risk of reduced pancreatic function.

AGC will find its main application in surgical and inpatient uses, eg in cardiac, neuro, burn, ICU, and people with diabetes in any hospital setting.

ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
There is a major IP holder in the space who is asserting their ownership, so even if they could solve the technical challenges, they might not be able to come to market.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
The difference is that these only measure blood sugar, while the new system also measures ketones, of keto diet fame, which are leading indicators of a really dangerous situation called diabetic ketoacidosis. It's treatable with a hospitalized IV insulin drip, but can be avoided if you have some advance notice.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
a regulated blood sugar level aids massively in cellular repair, inflammation reduction, and immune response. These are well studied and established. I could absolutely see a top athlete using AID in the future as part of a recovery routine, but I can also understand reluctance to adopt anything new or weird.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
non-invasive continuous blood sugar measurement is mired in patents and technical challenges. Turns out it's really difficult to disambiguate the absorption lines of glucose from other similarly shaped molecules when you're also dealing with untangling skin conductivity, transmissivity, sweat, inflammation etc.
ijustlovemath··on FDA authorizes first wearable device that monitors ketone and blood sugar levels
Automated glucose control will be the next frontier in so many areas of healthcare. I'm still skeptical that anyone will be able to noninvasively and accurately sense blood sugar, but I'm glad people (especially kids with T1) will have one more tool to help them. I hope they can figure out the reimbursement side to get it into the most hands possible!
ijustlovemath··on Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
I got my first one at age 27. A third just got removed. Living with the constant mole vigilance of that is rough, but I am glad I've learned to identify them. I think knowing the ABCDEs of it should be more widely spread, as removing a mole is a much nicer alternative to having to take margins in a highly mobile place.
ijustlovemath··on Back to Kagi
Curious what your distribution is, as a ~400 person that thought they did more.
ijustlovemath··on Jack Dorsey launches Buzz to combine team chat, AI agents and Git hosting
Why does Rust feel like a bad choice to you? In my experience shipping med device software, it's great for keeping the code that teams write cohesive and correct
ijustlovemath··on SQLite should have (Rust-style) editions
editions could be self-describing as to certain semantic changes, and you could embed that with the file. older versions could safely ignore it and newer versions parse and run it. you could also force things like "editions must be declared early", "editions are one way only" etc to get some level of security in the adoption of the change
ijustlovemath··on Briar is in maintenance mode
Helene survivor here. I will be spreading the word about this project and keeping some APKs for if the shit hits the fan again. FDroid being able to sync between local devices means all you need is to get fdroid onto someones phone. Wish they had an iphone app though!
ijustlovemath··on Podman v6.0.0
To be clear, all of that setup happens once on your host machine, then you never have to think about it again! You can compose to your heart's content. I think podman just doesn't want to commit to a particular DNS solution so they leave that decision to you.
ijustlovemath··on Podman v6.0.0
I had to do some extra stuff for my containers, here's some info from a tutorial I wrote:

Following the Arch wiki:

# Dependencies `yay -S podman slirp4netns aardvark-dns`

# Setup podman-compose and the venv ``` python -m venv .venv source .venv/bin/activate pip3 install --user podman-compose ```

On WSL, you'll need to be on Debian bookworm or newer. Older versions of podman-compose for, ie, bullseye, do not work.

# Reserving alternate UIDs/GIDs `# usermod --add-subuids 100000-165535 --add-subgids 100000-165535 username`

# Setup the storage configuration to overlay Create/edit the following file: `vim ~/.config/containers/storage.conf`

Add/edit the following line: ``` [storage] driver="overlay" ```

# Propagate changes to podman `$ podman system migrate`

# Bring the systems up `podman-compose up`

# I'm on WSL and it's not working (DNS issues)

Check if the network created by podman has dns enabled:

``` % podman network inspect $containername_default | grep dns "dns_enabled": true, ```

If it's false, install another dns resolver:

``` sudo apt install golang-github-containernetworking-plugin-dnsname ```

Then delete the network created by podman-compose:

`podman network rm $containername_default`

## Out of memory when running `podman-compose up`

This error may include "could not map anonymous shared memory".

If you're on a mac, try increasing the amount of memory the VM can use, eg:

https://stackoverflow.com/questions/70114200/increase-podman...

``` podman machine stop podman machine set --memory 4096 podman machine start ```

This will provide podman with 4GB of memory to work with when spawning containers.

https://gist.github.com/ijustlovemath/82b4fa31a7c745e87bac5f...

ijustlovemath··on Podman v6.0.0
what kind of stuff is in your compose?
ijustlovemath··on pg_durable: Microsoft open sources in-database durable execution
We made a very functional job queue in Postgres with PostgREST. highly recommend, as the automatic REST API makes building new clients a breeze
ijustlovemath··on Preparing for KDE Plasma's Last X11-Supported Release
Probably with Special Window Settings (right click top bar of your mpv window)
ijustlovemath··on Zerostack – A Unix-inspired coding agent written in pure Rust
Traits, Enums, and Typestate allow much richer paradigms at much lower cost
ijustlovemath··on I don't think AI will make your processes go faster
is it working though? The main outcome we've seen with companies that drink the AI Kool aid en masse is buggy unstable systems. clearly there's a level of rigor that's being missed for ship velocity
ijustlovemath··on Zerostack – A Unix-inspired coding agent written in pure Rust
When you write Rust long enough you settle on certain architectures (message passing, event loops) that go well with the borrow checker, and don't end up thinking about it too much. Plus you can always throw an agent at the first set of errors from the refactor and let the compiler guide the annoying parts.
ijustlovemath··on A.I. note takers are making lawyers nervous
It seems like the problem in this application is that attention itself. Makes me wonder if using a transformer for transcription is the correct architecture.
ijustlovemath··on The quiet resurgence of RF engineering
While not an RF book per se, High Speed Digital design does a great job of spanning the gap from EE undergrad to the basics of RF as it relates to digital design. I'd also recommend brushing up on more advanced E&M, eg T{E,M} modes and antenna design if you haven't looked at them in a while
ijustlovemath··on Amateur armed with ChatGPT solves an Erdős problem
No mention of how he was essentially homeless and collabed his way thru thousands of papers? Or the whole "You have set mathematics back a month" episode?

Absolute legend!

ijustlovemath··on As oceans warm, great white sharks are overheating
During the Paleocene-Eocene Thermal Maximum, the rate of change of CO2 concentration was 1/4 what we're at today
ijustlovemath··on My adventure in designing API keys
JWT operates on a different principle; the user's private key (API key) never leaves the user's device. Instead, the stated "role" and other JSON data are signed with the servers pubkey, then verified by the server using its master key, granting the permissions that role allows.
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