internet_user

Time for international oversight of unethical, extremely hazardous biological research.

If nuclear can be supervised and contained - you can contain gain of function research too.

They've had enough biosafety incidents to have the WHO themselves call them on it in the past.

SARS, according to WHO, was a lab break too.

What kind of damages would China be liable for 50-60% globally infected, with 3-4% deaths?

That is why the evidence will be suppressed, and the inconvenient voices silenced.

We don't need new drugs.

Outbreaks will continue on happening as long as we have gain of function research programs in place.

They will literally try to come up with new strains resistant to current treatments, if such research continues to be done.

Time for international oversight, just like with nuclear.

We need to stop unethical gain of function research. It should only ever be approved if the outbreak can be actually contained and victims treated - with monetary penalties in place for consequences.

Only this outbreak had nothing to do with the market, the index case had no connection.

"Breaches of safety regulations are probable cause of recent SARS outbreak, WHO says"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416634/

https://www.the-scientist.com/news-analysis/sars-escaped-bei...

https://www.voanews.com/archive/who-beijing-lab-blame-sars-o...

Lab breaks of SARS, another coronavirus have happened a number of times, and likely caused the original SARS outbreak (according to WHO)

This regional phenomena happens to be right across the river, 20 miles, next to the only BSL4 level lab in the region.

That same lab also happens to have published hundreds of synthetic coronavirus genomes. They also ran gain of function research that was banned by NIH until recently, due to it's highly questionable ethics and biosafety in principle.

It's just another lab break, why is it so hard to accept that industrial accidents happen?

chloroquine is not frequently used for autoimmune. At doses used for corona, it is within 50% of margin, or even lower if you are a slow metabolizer of an LD50 dose.

plaquenil on the other hand does have a higher therapeutic index.

The other major disadvantage is that these drugs can interact with protease inhibitors.

Therapeutic index of chloroquine isn't very high, and at the doses it's recommended for corona it's rather close to lethal doses, something like within an order of magnitude.

Malaria prophylaxis is dosed -once- a weeek. Half-life 60-70 hours. Covid treatment is -twice daily-.

"Invert, always invert" - Jacobi.

It would be essentially a clinical trial, an open-label one.

There even have been several blinded trials, that were discontinued mid-way, because the drugs being tested were so effective.

To continue giving placebo and denying obvious cure would be unethical, and so the trial was stopped, placebo arm cancelled - and everyone got the actual medicine.

bank cards can be tapped on NFC terminals: ISO/IEC 14443

What is the security model delta here?

The price of bank cards to users is blended into the product, however, some charge a low single dollar digits for frequent replacements.

It's not at all unexpected a key card for a Tesla would be low.

Seems to be $25, which is much cheaper than most remote keys.

https://shop.tesla.com/product/model-3-key-card

bank cards with identical security (secure element) cost well under $5, in bulk maybe even under a dollar.

It's amusing in some ways.

We already have an informal FAANG guild: 1) their salaries are higher 2) FAANG on the resume = already vetted 3) mastered the interview rigmarole

So it seems that efforts by employers to collude in the job market led to something that resembles a professional guild.

key travel is still too limited, bottoms out immediately.

Are you suggesting physicians are uncomfortable treating somatization disorders or something?

Your comment makes a lot of assumptions: 1) physician is qualified and competent. 2) diagnosis is correct. 3) treatment is optimal.

Those are all big assumptions. Misdiagnosis and inappropriate treatment are very, very common. "Placebo" prescriptions are common. Something like 25% of presentations at primary care are for medically unexplained symptoms.

However, any half-decent physician will attempt to address obvious psychopathology, if present. I don't believe it is commonly being ignored.

I don't know your case specifics, but in presence of objective abnormalities - there is obviously going to be hesitation to diagnose somatoform.

Amazing how conversations swing from one side of extreme to another in just two comments.

What's next, are you going to suggest basilar skull fractures are somewhat linked to emotional stress?

The responses you'd get would likely be due to PTSD induced by interacting with the very rational and scientifically-minded profit-maximizing medical industry, and/or incompetent physicians unable to provide an effective relief for the underlying condition.

Try out this some time: try to reduce stigma around various disorders instead of suggesting running nonconsensual unethical experiments, bordering on sociopathy, on those suffering from difficult to treat disorders.

You could have hormetic effects from psychological stressors as well.

They really are identical on a certain level.

What gives you the impression medical profession doesn't do anything with it?

Sapolsky (h-index 109) was McEwen's student, probably one of his most prominent students, and has continued to work on stress, as did his other students.

Sapolsky alone made enormous contributions to our understanding and treatment of stress and stress-related disorders.

16" Pro has a physical ESC key. keyboard still sucks just as bad.

even if you have very very generous welfare (and I agree that this should exist) - it would not ever fix the inequality of outcome.

I just don't see how those who can perform literally 10x more productively than others will settle for less than an absolute top prize, and with technology being such a great amplifier - winner take all dynamics seems to be so inherent - I am not even sure what can be done?

All of Apple keyboards are terrible. 16" Pro keyboard is still terrible, only very marginally better than previous model.

how do you propose we fight inequality? Inequality of outcome?

That's been happening already across the board: medical costs, housing costs, etc. anywhere where demand is fairly inflexible.

what is FSD in this context? fully self-driving?

how is that measured? what are the tests that measure for it? tia

Implicit learning is real. Some guts are more accurate than others. Just like not everyone is a great logician.

Yes, Gabriel Leung is the correct name. Thank you.

His name is Gabriel Leung, dean of hong kong's school of medicine.

https://www.scmp.com/news/hong-kong/health-environment/artic...

his live interview: https://www.youtube.com/watch?v=aYyH4N8VXvA

https://www.tellerreport.com/news/2020-01-27---viruses--hong...

He expects 150k infections daily at some point: https://www.ccn.com/dramatic-hong-kong-data-predicts-coronav...

Thank you for posting that video. He sounds most reasonable and with zero slogans, and even though with restraint he certainly thinks this can spin out of control.

Nobody blockades 10 cities and quarantines 50 million people over 100 deaths.

Shanghai closed all non essential businesses. Schools closed until Feb 17th. Hongkong is in state of emergency.

Several military medical battalions have been deployed overnight in China.

This is not a drill.

Everyone is so fixiates on deaths.

25% of SARS survivors have lungs mangled so badly they cannot exercise or walk very much. Does that count as healthy adults not dying?