To make some sweeping generalisations, Pythonistas tend to be more computer-sciencey than the Ruby crowd, and if you're doing a lot of heavy number crunching, it might be worth checking out SciPy/numpy and whether there are equivalent stacks in Ruby (I have done this research but my gut says there aren't.) OTOH, the sheer size and popularity of RoR means that it's much easier to find work in Ruby/Rails than Python/Django. YMMV.