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killjoywashere

8,744 karma · joined February 6, 2017

human dot embryology at gmail

Interesting bookmark: https://news.ycombinator.com/lists

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killjoywashere··on Carbon capture more costly than switching to renewables, researchers find
Is it possible to just pump a slurry of corn and various pulp products into dead oil wells?
killjoywashere··on AI Is Stifling Tech Adoption
Interesting. Do you see any versions of the future where use of AI could actually make the physician take more time?
killjoywashere··on AI is stifling new tech adoption?
Not if they're trained to work through the problem each time they encounter it and stay up with their clinical training. The day the new classification drops many have already heard about it.

You also assume that all the models in use will in fact be retrained.

Generally, this position flies in the face of lived experience. AI is in fact stifling adoption of new things across many industries.

killjoywashere··on AI Is Stifling Tech Adoption
I'm familiar with the linked study, which presents legitimately challenging analytic problems. There's a difference between challenging analytic problems and new analytic problems.

A new platform poses new analytic problems. A new edition of the WHO's classification of skin tumors (1), for example, presents new analytic problems.

(1) https://tumourclassification.iarc.who.int/chapters/64

killjoywashere··on AI is stifling new tech adoption?
Pathologists as a specialty has been grousing about this for several years, at least since 2021 when the College of American Pathologists established the AI Committee. As a trivial example: any trained model deployed will necessarily be behind any new classification of tumors. This makes it harder to push the science and clinical diagnosis of cancer forward.

The entire music community has been complaining about how old music gets more recommendations on streaming platforms, necessarily making it harder for new music to break out.

It's absolutely fascinating watching software developers come to grips with what they have wrought.

killjoywashere··on Dose-dependent effects of LSD in double-blind placebo-controlled study (2020)
Am op, sorry haven't had my coffee yet. Yeah, agree with noem. These curves would be smooth for a 3000-subject phase 3 trial. For 16 people? The error bars are even weirdly tight. One general truism: all the normals are the same, but abnormals are increasingly different in different ways. That gets more true as people get older, they just accumulate more varied life experience. Just looking at the participants section,

> "eight men and eight women; mean age ± SD: 29 ± 6.4 years; range: 25–52 years"

> "The participants were asked to consume no more than 10 standard alcoholic drinks/week and have no more than one drink on the day before the test sessions."

> "Drug administration timing did not consider the menstrual cycle in females for practical reasons. Four women used a hormonal contraceptive and one was menopausal."

> "Six participants had previously used LSD (1–3 times), eight participants had used methylenedioxymethamphetamine (MDMA) (1–5 times), ten participants had previously used a stimulant, including methylphenidate (four participants, 1–2 times), amphetamine (six participants, 1–3 times), and cocaine (two participants, 1–2 times), and one participant had smoked opium (once)."

These are not your standard young, male athletes you'd typically desire for a tightly controlled result.

killjoywashere··on Dose-dependent effects of LSD in double-blind placebo-controlled study (2020)
Skimmed this. Is it just me or does the data look a little too perfect?
killjoywashere··on Stop using zip codes for geospatial analysis (2019)
Same! My wife ran a business from home during the pandemic and we actually went through the effort to work with Google Maps (they called us) to get it on the map. And of course USPS has no problem. But our address was originally a federal building with a letter, still only has a letter, no number, and there are now all sorts of work-arounds floating around on how resolve addresses in our neighborhood. What's wild is the Post Office is literally down the street from our house, and our house predates the founding of most of the big delivery services, which all manage to deliver to us, given their preferred incantation. If I can't get the shipper to pass the right incantation to their shipping service, shenanigans ensue. My (least?) favorite was an item that went across the Pacific Ocean 3 times over the course of 3 months.
killjoywashere··on Stop using zip codes for geospatial analysis (2019)
ZIPs are also specifically used in a variety of medical, epidemiologic, public health contexts and HHS has explicit, fairly fine-grained rules on their use: https://www.hhs.gov/hipaa/for-professionals/special-topics/d...
killjoywashere··on Microsoft Go 1.24 FIPS changes
Please, does this make it possible for me to send an email from Outlook to GMail encrypted using US government PKI?
killjoywashere··on Giant, Mysterious Spires Ruled the Earth Long Before Trees Did
I wonder if they're something structurally akin to cypress knees: either structural buttresses or pneumatophores?
killjoywashere··on The Tyranny of Structurelessness (1970)
Every data structure comes with costs. You give some to get others. Nothing in here should be surprising.
killjoywashere··on Road signs to help people limit radiation exposure in contaminated areas
The Yalu River separates China and North Korea. General MacArthur sent US troops across the Yalu, which is what caused the Chinese to enter the Korean War, and led to most of the US casualties. Truman fired MacArthur for disobeying his order to stay on the Korean side of the Yalu. That was before the Chinese had nuclear weapons. The Korean peninsula has been under an armistice and not at peace for 70 years in large part because MacArthur invaded China in I would characterize as a Cabinet war mentality. Go to the MacArthur museum in Norfolk, Virginia. MacArthur was from an extraordinarily wealthy family and clearly saw himself as an aristocrat with warrant to act unilaterally while deployed far afield.

If the US sent its own troops to invade China today, do you think we be here to talk about it tomorrow? That would be no Cabinet war.

killjoywashere··on Road signs to help people limit radiation exposure in contaminated areas
If we crossed the Yalu River today, do you think we'd be alive tomorrow to talk about it? Nuclear deterrence, as part of the taboo, prevents any nation from violating the sovereignty of a nuclear power. The only exception I know of is the Yom Kippur War, and if there is ever a person who never received a well-earned Nobel Peace Prize, it's Golda Meir.
killjoywashere··on Road signs to help people limit radiation exposure in contaminated areas
> engineers mused over whether there was anything to be done top stop a torrent of enemy missiles falling across the nation. These superweapons seemed to promise destruction on an overbearing scale, threatening the very existence of human civilization itself.

THEY STILL DO!!!!

This is what drives me nuts about our politics: so many people seem to think we can flirt with the sort of nationalism (1) that led us into WWI and WWII. But, friends, that road leads to your death in every direction. Mutually Assured Destruction is still a thing. Nuclear peace only works as long as all parties persistently work toward de-escalation, which can be measured by adherence to consensus and norms. Nationalism is antithetical to that posture. The iconoclast leaders of national populism are rooted in rulebreaking. They also tend to embrace strong foreign policy talk as a short term bolster to domestic support, again, antithetical to de-escalation.

(1) https://en.wikipedia.org/wiki/Nationalism

killjoywashere··on Climbers using xenon gas to climb Everest
ah, rich people sports...
killjoywashere··on Apple squandered the Holy Grail
As a daily driver laptop, a MacBook Pro just sucks less than everything else.
killjoywashere··on Why are cancer guidelines stuck in PDFs?
The cancer reporting protocols from the College of American Pathologists are available in structured format (1). No major laboratory information system vendor properly implements them, properly, and their implementation errors cause some not-insignificant problems with patient care (oncologists calling the lab asking for clarification, etc). This has pushed labs to make policies disallowing the use of those modules and individual pathologists reverting to their own non-portable templates in Word documents.

The medical information systems vendors are right up there with health insurance companies in terms of their investment in ensuring patient deaths. Ensuring. With an E.

(1) https://www.cap.org/protocols-and-guidelines/electronic-canc...

killjoywashere··on OpenAI O3 breakthrough high score on ARC-AGI-PUB
I just want it to do my laundry.
killjoywashere··on Ghost artists on Spotify
How much of my money am I supposed to fork over to streaming companies? Tidal, Qobuz, SoundCloud, YouTube Music, Deezer, Amazon Music, Apple. And how much work am I supposed to invest in migrating my playlists between them? I don't want to invest my time in digging through every new artist (SoundCloud?), at the same time, I occasionally find a deep rabbithole I want to go down. How do I go spelunking if the archive isn't deep and rich?
killjoywashere··on Library Thing Is Down?
https://isdownstatus.com/status/librarything.com
killjoywashere··on Launch HN: Azalea Robotics (YC S24) – Baggage-handling robots for airports
surely someone thought of this before though. There must be a "why not" answer already.
killjoywashere··on Launch HN: Azalea Robotics (YC S24) – Baggage-handling robots for airports
ah, liquid metal, why didn't I think of that!
killjoywashere··on Launch HN: Azalea Robotics (YC S24) – Baggage-handling robots for airports
Why not rear-load like military aircraft and avoid that 90º turn? Then you could have a hull-shaped hopper to drop the bags in, so they are tetris'd together in the right geometry before you get to the ramp. Roll the hopper in, have a pez-despenser style pusher so as you withdraw the hopper, the bags are left behind in the aircraft?
killjoywashere··on OnlyFans models are using AI impersonators to keep up with their DMs
More true than you might think: rat poison (coumadin) saves lives as an anticoagulant. Conversely, Tylenol can kill you. Very few non-smoking alcoholics have serious atherosclerosis on autopsy, but lots of people die of alcoholism. Life finds a way. Or sometimes not.
killjoywashere··on How Typing Transformed Nietzsche's Consciousness
Typing has a certain reward function to it: that snap-snap-snap is satisfying. I wonder if he just got addicted to it?
killjoywashere··on Engineering Sleep
> The UCSF group hypothesizes that this elevated level of orexin expression partially explains reduced sleep

So, one possible line of investigation would be a table of mammals, their sleep cycles, their orexin levels, and the numbers of copies of orexin and it's regulators in their genomes. For example: compared to humans, elephants have a lower cancer risk. Turns out they have significantly more copies of p53, a tumor supressor gene (1).

Perhaps a similar, somewhat parallel construct exists: elephants sleep 3-4 hours a night. Maybe they have more orexin? Maybe they have different copy numbers or mutations of the relevant genes in the pathway?

(1) https://pmc.ncbi.nlm.nih.gov/articles/PMC5061548/

killjoywashere··on The deterioration of Google
The difference between theory and practice is that, in practice, all theoretical exponentials are eventually sigmoid and, in the very long run, bell-shaped.
killjoywashere··on Artificial Intelligence and the Future of Work
> This reveals the real problem: it is about jobs, not data.

I think you're selling "it is about jobs, not data" a little short here.

Let me start off by saying I work on AI for healthcare, my first IRB protocol that contemplated computer vision is from 2012. I'm not an OG, but I've been working on this stuff for a while, and I'm very bullish.

On the flipside, my wife is a pediatric occupational therapist, she works with autistic kids. Kids in the Bay Area. Her clients are Google machine learning engineers. The major issue with jobs is not so much the monetary value of the work, although that's an important secondary outcome.

Humans need an occupation. Occupation is the purpose of life. Long before money was a thing, we needed purpose. Even kings and their courtiers, before money, needed occupations. We need to be doing something. People change their occupations from time to time. It doesn't have to be a job. It could be a hobby, in some cases. Even kids want to contribute. Even infants, as soon as they understand and can, will reach out to console or delight their caregiver. But we need to feel like we are giving back. Our minds and muscles atrophy if we are not occupied.

If we attach everything to solar power and let the machines run the world, we'll end up some version of the blob people in Wall-E's Buy n Large spaceships. The reward at the end of the movie was the people getting off the space ship, thanking the robots for giving them back purpose, mainly to restore their planet.

Purpose and occupation are about so much more than money.

killjoywashere··on Artificial Intelligence and the Future of Work
> pro-free-cultural moral views

Mike Montero would like a word

"Who in this room is now, or has at some time, been in creative services?

"Who here has, at some time, had trouble getting paid by a client for work they were doing?

"Raise your hand if any of these are familiar to you:

"'We ended up not using the work.'

"'It's really not what we wanted after all.'

"Alright. Who's familiar with Goodfellas?

"Alright. 'We got somebody internal to do it instead.'

"'Fuck you. Pay me.'"

"'Fuck you. Pay me.'"

https://www.youtube.com/watch?v=jVkLVRt6c1U

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