HNHacker News
TopNewBestAskShowJobs

kleton

1,102 karma · joined October 20, 2018

submissionscomments
kleton··on Zebrafish protein unlocks dormant genes for heart repair
It is a protein that exists in mammals. Presumably they produced the murine version to put in the mouse. Science journalism screwed up the paper's language, calling it a zebrafish protein, when it is a protein that is conserved for all vertebrates. But the function of the protein, and its role in heart regeneration, was identified in zebrafish.

> Directly after LAD ligation during MI surgery, hearts were injected twice with 15 μl of AAV9(CMV:GFP) or AAV9(CMV:HA-Hmga1) (1 × 1012 virus particles per mouse) in opposing regions bordering the area at risk of ischemic injury.

The paper doesn't say whether the viral vector (AAV9) used the murine or zebrafish Hmga1 sequence, but it is more likely that they used the murine.

kleton··on PlasticList's Advice for Food Companies
Silicon dioxide is not chemically toxic. But you can put microfiber crystals of it in a mammal's lungs and get tumors that grow around them. It is not a huge stretch of the imagination from there to hypothesize that nano- and micro-particles of a nontoxic polymer could also cause problems.
kleton··on H5N1: Much More Than You Wanted to Know
If there were two things going around January 2020, I would have gotten both of them. This is common sense to anyone who has had school age children.
kleton··on H5N1: Much More Than You Wanted to Know
In previous generations there was a sense that the elderly had already lived their best years, and the young should be prioritized in emergencies. "Women and children first" The American Boomer generation flipped this on its head, with them demanding the young make sacrifices for them.
kleton··on H5N1: Much More Than You Wanted to Know
You literally said "isolate". Now you have retreated to the motte of common sense hygiene that nobody ever objected to.
kleton··on H5N1: Much More Than You Wanted to Know
One thing remained clear from the time I got Covid the first time- people with natural immunity should be allowed to return to going about their normal lives.
kleton··on H5N1: Much More Than You Wanted to Know
There was only one thing going around in the Bay Area in January 2020, and the symptoms clearly lined up for everyone in my network.
kleton··on H5N1: Much More Than You Wanted to Know
If you lock down everyone, or just lock down the elderly, what is the difference to the elderly person locked down? Either way they are isolated.
kleton··on H5N1: Much More Than You Wanted to Know
I'll stay home
kleton··on H5N1: Much More Than You Wanted to Know
I had recovered from it in about January 2020, so it was not one bit uncertain to me.
kleton··on H5N1: Much More Than You Wanted to Know
Quarantine, voluntary or otherwise, the elderly and at-risk then. In the Bay Area, anyone who had children in daycare had already gotten Covid and recovered from it before the lockdowns began. A rational policy needed to recognize natural immunity.
kleton··on H5N1: Much More Than You Wanted to Know
It was clear to people paying attention to the hard numbers by February 2020 that Covid was no threat to children and non-elderly adults without risk factors like obesity, which led to the rational decision to treat it as a non-risk. If something bad comes around that is actually killing healthy adults, they would stay home.
kleton··on China to Build Thorium Molten-Salt Reactor in 2025
About one third of China's politburo, including Xi Jinping, have degrees in Engineering. The West's leadership is all attorneys or finance.
kleton··on WSDA, USDA announce eradication of northern giant hornet from the United States
They could have gone with northern asian hornet, to follow proper taxonomy of including general and specific.
kleton··on WSDA, USDA announce eradication of northern giant hornet from the United States
This is the Asian giant hornet. Apparently they had to make a euphemism that would obfuscate the continent of origin, when being from the wrong continent is precisely the reason it needed to be eradicated.
kleton··on A 10-Year Battery for AirTag
What kind of anarcho-tyranny is that?
kleton··on Torpedo juice: Legendary, illegal WWII liquor drunk in Alaska and the world
Acetone–butanol–ethanol fermentation was itself a critical WWI technology, as cordite required acetone. That fermentation process requires only sugars and an acetobutylicum strain. The first president of Israel developed this process.
kleton··on U.S. math scores drop on major international test
Common core was rammed through to prod without proper a/b testing or canarying. All the criticisms of the "New Math" of the 1960s are just as applicable to it today. See Morris Kline's «Why Johnny Can't Add» on archive.org.
kleton··on One of the last Navajo code-talkers died on October 19th, aged 107
It was deeply ingrained by their internecine conflicts. When factions would fight in their internal wars, they would expect the losing side to commit suicide if they happened to be defeated and not dead by enemy hands. Their military class was not introspective enough to consider that implication of this, if applied to its logical end in a conflict with an out-group, would be the total extinction of their ethnic group.
kleton··on Alzheimer's study shows ketone bodies help clear misfolded proteins
The usual Ramadan regimen for Muslims involves carbo-loading with dates and sugars in the morning, so it is unlikely to get to ketosis by iftar.
kleton··on Good union types in Go would probably need types without a zero value
The exact quote

> The key point here is our programmers are Googlers, they’re not researchers. They’re typically, fairly young, fresh out of school, probably learned Java, maybe learned C or C++, probably learned Python. They’re not capable of understanding a brilliant language but we want to use them to build good software. So, the language that we give them has to be easy for them to understand and easy to adopt

kleton··on Unique killer whale pod may have acquired special skills to hunt whale sharks
They probably have ancient oral history that that's a bad idea.
kleton··on Francis Crick's "Central Dogma" was misunderstood
It is difficult to entirely avoid contamination by DNA. https://x.com/p_j_buckhaults/status/1861083163868672204
kleton··on Evidence of oldest known alphabetic writing unearthed in ancient Syrian city
Egyptian is afro-asiatic but not semitic, like Berber, somali and others
kleton··on Undergraduates with family income below $200k will be tuition-free at MIT
A sham marriage (get a prenup if you want) is sufficient to have parents' income not counted by FAFSA.
kleton··on Teens learn a new conspiracy theory every week on social media
You actually wouldn't need any stats classes to do this particular analysis, the sample sizes are quite large. You only need to know four values, the size of the groups of all vaccinated or unvaccinated, and the numerators, the number of incidents of cancer in both groups, to determine if there is a difference in the incidence rate between the two populations.
kleton··on Teens learn a new conspiracy theory every week on social media
There exist several US federal bureaus, such as the census and labor statistics ones, that have built and maintained widespread trust in publishing accurate tabulations. It is not an impossible problem.
kleton··on Teens learn a new conspiracy theory every week on social media
> hodgkin's lymphoma from The Vax.

Rather than censorship, a better way of combatting this sort of rumor would be a government agency, for example, one that would be put in charge of food and drugs, collecting and publishing k-anonymized incidences of disease annotated by such things as what drugs and risk factors groups of individuals were subject to. This would allow such claims to be evaluated empirically.

kleton··on MIT engineers make converting CO2 into useful products more practical
If they are sequestering by reducing (in the sense of donating electrons to) carbon, then that will, by thermodynamic necessity, require more energy input than oxidizing that carbon originally provided. Converting to ethylene, as they mention in the article, is such a process.
kleton··on An unearthly spectacle – The untold story of the biggest nuclear bomb (2021)
Russians now pay a third or less what you are probably currently paying for eggs.
← PreviousPage 4 of 13Next →