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liquid_thyme

251 karma · joined January 10, 2025

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liquid_thyme··on Kagi News
Is the future where we pay a premium for human generated content?
liquid_thyme··on What is “good taste” in software engineering?
You can never predict with 100% certainty, unless you're building a clone.
liquid_thyme··on What is “good taste” in software engineering?
Bad Taste Leads to X; We're trying to avoid X. To me, it is closely aligned to predicting the future of a code base. So really, good taste is about navigating future uncertainty by laying down foundational elements that protect against the uncertainty so you don't drive off a cliff.
liquid_thyme··on Greenland is a beautiful nightmare
Driving through is fine, but realistically, if you need basic amenities (healthcare, groceries, etc), you will be living in or around a population center, so those numbers won't hold up.
liquid_thyme··on How to Lead in a Room Full of Experts
The only thing that matters is - Have you personally implemented your ideas in the real world or not? I don't care much for theoretical mumbo jumbo. You keep doing your thing and I'll keep doing it my way that I know works. It is irrelevant what you can "confirm" about me and my views - what a pompous thing to say!
liquid_thyme··on The "Wage Level" Mirage: H-1B proposal could help outsourcers and hurt US talent
Take a look how many brown people have left their country of origin and are doing science in the US, writing code for big tech, and contributing to the economy. It doesn't mean that the entire worlds population should be encouraged to move to the US. And maybe the right answer for us is to slow down immigration, but fuck... how about just a thank you for all the people who are working hard out here? I don't think these people deserve to be demonized as much as they have been by this administration.
liquid_thyme··on How to Lead in a Room Full of Experts
>Weigh all the pros/cons and make a choice.

This is sound advice when people agree on which column things belong to :)

liquid_thyme··on How to Lead in a Room Full of Experts
I've worked with engineers like this, who have a massive god-complex. If you think your job is to second guess your manager's knowledge and experience, why are you working under them? You should be working as a manager somewhere else. You are not a peer, you're part of a team reporting into a person that company has entrusted to lead the team.
liquid_thyme··on New bacteria, and two potential antibiotics, discovered in soil
You're correct, I'm wrong!
liquid_thyme··on New bacteria, and two potential antibiotics, discovered in soil
In the domain of natural sciences, throughout history, there have been periods of high and low rate of progress. All you have evidence for is that progress has slowed down and your own personal belief linking it to another event in history (among thousands of events) - But you haven't shown any positive evidence of something being lost (i.e. scientific data/research), besides arguing for it with words. Sorry, your so called reasonable inference doesn't seem reasonable to me.
liquid_thyme··on New bacteria, and two potential antibiotics, discovered in soil
>The problem was that it wasn't more effective than the existing standard of care; it was only equally effective.

That is misleading. When a clinical trial is designed for non-inferiority, it doesn't say anything about being superior or equal. Just as legally, a defendant is either guilty or not guilty - there is no legal adjudication of being "innocent".

These drugs are not comparable (different stability profiles, different mechanisms of action, etc) and to say they're equal is highly misleading.

>and the absence of the drugs that would have been discovered since then has surely killed many more people than the inadvertent use of harmful drugs ever could have.

There is no evidence that safety regulations have denied us some miracle drug. I don't want the FDA approving drug products that are harmful to the general population. You haven't made a good argument for "the greater good" besides a reference to magainin, a product for topical treatment of foot ulcers. There are thousands of known anti microbial peptides.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7937881/

liquid_thyme··on New bacteria, and two potential antibiotics, discovered in soil
Edit: nvm, brain fart. OP is correct.

> So being able to make the product without culturing the organism is key.

No, it isn't. The article talks about using chemical synthesis, rather than using a biological platform to express the product via genes.

"To convert the newly uncovered sequences into bioactive molecules, the team applied a synthetic bioinformatic natural products (synBNP) approach. They bioinformatically predicted the chemical structures of natural products directly from the genome data and then chemically synthesized them in the lab. With the synBNP approach, Brady and colleagues managed to turn the genetic blueprints from uncultured bacteria into actual molecules—including two potent antibiotics."

liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
IMO, the larger economic framework and current political climate is whats causing the breakdown of trust, more than anything else. Many citizens have switched off from politics, simply don't care, or are busy trying to put food on the table. The presence of an insignificant number of temporary workers isn't going to change whether the US becomes a high-trust society. We're going around in circles here, so lets move on..
liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
I don't fix security bugs by requesting people to not exploit them.
liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
Great, so if they're as obviously bad as you claim, then it should be easy to weed them out for any competent HR department. And if the HR department isn't competent, the company is going to fold. Either way, problem solved.

You felt it appropriate to jump on your little throne and pass judgement on large groups of people, but cried ad-hominem when I slightly criticized you. Sensitive much?

liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
There is shortage of everything now. Maybe immigrants needing gas is raising gas prices too. (OK, i know you didn't say that, but its a joke :P) We could go back and forth posting links that contradict each other, or recognize that scapegoating immigrants isn't productive.

https://www.uschamber.com/economy/the-state-of-housing-in-am...

"The shortage of housing can be attributed to a range of regulatory and policy failures. These include burdensome permitting processes, outdated zoning regulations that dictate everything from lot sizes to parking requirements, complex legal frameworks, price controls, and restrictive financial regulations."

liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
So your employer's interview process isn't able to differentiate between a fake degree holding scammer and you? I'd focus on that first...
liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
Okay, you said scam, not steal. You didn't write much of anything except throw wild accusations.
liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
> who compete for housing with citizens when there is a shortage of millions of housing units.

Are they underpaid, or are they swimming in cash to buy up all the expensive housing? Make up your mind.

liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
Thats complete bullshit. Nobody can "steal" a job. Americans are lining up to give them jobs.
liquid_thyme··on Trump to impose $100k fee for H-1B worker visas, White House says
Ask the native americans how they feel about being "replaced"? Maybe the cycle just repeats itself - if you live long enough to see it. I heard they used to speak French in England.
liquid_thyme··on Samsung forces ads onto fridges; is a bad sign for other appliances
Why pay for advertising, when you can show your ads on your own devices for free? Heh..
liquid_thyme··on Ask HN: Dark Mode for HN?
A+++ , would buy again, :)
liquid_thyme··on Chrome's New AI Features
A lot of these new AI features can be helpful as long as the users' control the data. Is there an alternate world where Google might become the good guy here? In this world, as might be expected, the company making the worlds best spyware, wants to expand its spying.
liquid_thyme··on Boring work needs tension
Not to be personal, but you sound quite naive. The world is ugly and runs on money/power/leverage/arm-twisting. The "nice" people who lay down their arms get invaded and conquered, and thats the end of that gene pool.

Side note: For Americans, the ability to stay blissfully unaware of all of this is due to the 76 US Navy Destroyers and 11 aircraft carriers that are ready and willing to enforce/maintain/defend the current way of life for the civilian population.

liquid_thyme··on Boring work needs tension
First and foremost, good for you! Its a guess, but it seems you have a lot of control over your work, schedule, terms, etc than most people, or are in a very high position where you're in the drivers seat, creatively. We all would like greater agency, but that ain't the case for the overwhelming majority of working professionals.
liquid_thyme··on Boring work needs tension
>But if you say "this work will get the client's hospital equipment monitoring suite out sooner; if it works reliably, they'll be able to deploy it sooner, and it'll save the lives of some sick kids," then that'll also get the work done a little faster, and it'll make you feel good about doing it.

The problem is that the smart ones will easily figure out that 'this next version will save lives' is a total lie. If your monitoring product doesn't work, it gets dumped and replaced. In developed countries, if your code has the potential of harming someone you're in a heavily regulated industry. The software in those industries is speced out in enormous detail to avoid this problem.

>Arbitrary tension is a patch that you put on work that has no meaning. "We want you to go faster because it will make our metrics go up which might raise the stock a few percentage which might make our investors a few extra millions" has no meaning, which is the root problem.

I disagree. Financial goals are the easiest to understand for people, and also easiest to communicate, and personally for me easiest to reason about how to achieve them. Just hit a number and you're done, collect your bonus and go do something you enjoy. As they say, the best way to ruin something you love doing is by making it your job. IMO people who chase some higher purpose and meaning are destined to be forever unhappy at their job.

liquid_thyme··on Meta bypassed Apple privacy protections, claims former employee
There are people who care about keeping phones out of landfills and Apple (and others) designing products withe low repairability, and also trying their best to block access to parts under the guise of "protecting" the users.
liquid_thyme··on Meta bypassed Apple privacy protections, claims former employee
So is Google and Apple themselves. There is no entity here which is a paragon of virtue in the valley. I do believe that cynicism is detrimental to mental health, and hope stems from assuming things can and do get better sometimes.
liquid_thyme··on Apple restricts Pebble from being awesome with iPhones
You have your own viewpoint, and are assuming its "resonable" and so by definition I'm "unreasonable" is GOOD FAITH? No thanks, no interest in engaging with you.
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