251 karma · joined January 10, 2025
This is sound advice when people agree on which column things belong to :)
That is misleading. When a clinical trial is designed for non-inferiority, it doesn't say anything about being superior or equal. Just as legally, a defendant is either guilty or not guilty - there is no legal adjudication of being "innocent".
These drugs are not comparable (different stability profiles, different mechanisms of action, etc) and to say they're equal is highly misleading.
>and the absence of the drugs that would have been discovered since then has surely killed many more people than the inadvertent use of harmful drugs ever could have.
There is no evidence that safety regulations have denied us some miracle drug. I don't want the FDA approving drug products that are harmful to the general population. You haven't made a good argument for "the greater good" besides a reference to magainin, a product for topical treatment of foot ulcers. There are thousands of known anti microbial peptides.
> So being able to make the product without culturing the organism is key.
No, it isn't. The article talks about using chemical synthesis, rather than using a biological platform to express the product via genes.
"To convert the newly uncovered sequences into bioactive molecules, the team applied a synthetic bioinformatic natural products (synBNP) approach. They bioinformatically predicted the chemical structures of natural products directly from the genome data and then chemically synthesized them in the lab. With the synBNP approach, Brady and colleagues managed to turn the genetic blueprints from uncultured bacteria into actual molecules—including two potent antibiotics."
You felt it appropriate to jump on your little throne and pass judgement on large groups of people, but cried ad-hominem when I slightly criticized you. Sensitive much?
https://www.uschamber.com/economy/the-state-of-housing-in-am...
"The shortage of housing can be attributed to a range of regulatory and policy failures. These include burdensome permitting processes, outdated zoning regulations that dictate everything from lot sizes to parking requirements, complex legal frameworks, price controls, and restrictive financial regulations."
Are they underpaid, or are they swimming in cash to buy up all the expensive housing? Make up your mind.
Side note: For Americans, the ability to stay blissfully unaware of all of this is due to the 76 US Navy Destroyers and 11 aircraft carriers that are ready and willing to enforce/maintain/defend the current way of life for the civilian population.
The problem is that the smart ones will easily figure out that 'this next version will save lives' is a total lie. If your monitoring product doesn't work, it gets dumped and replaced. In developed countries, if your code has the potential of harming someone you're in a heavily regulated industry. The software in those industries is speced out in enormous detail to avoid this problem.
>Arbitrary tension is a patch that you put on work that has no meaning. "We want you to go faster because it will make our metrics go up which might raise the stock a few percentage which might make our investors a few extra millions" has no meaning, which is the root problem.
I disagree. Financial goals are the easiest to understand for people, and also easiest to communicate, and personally for me easiest to reason about how to achieve them. Just hit a number and you're done, collect your bonus and go do something you enjoy. As they say, the best way to ruin something you love doing is by making it your job. IMO people who chase some higher purpose and meaning are destined to be forever unhappy at their job.