244 karma · joined January 12, 2017
If you can take away the need for millions of dollars to run a campaign then policy makers aren't beholden to the few wealthy supporters that helped get them elected.
They help connect volunteers to projects that range from building an open-source voter database to an Uber-like app that helps the mobility-limited get transportation to vote. They are extremely transparent and always interested in growing the network. Many members of the network are engineers, product managers, or independent coders.
As the author mentions, certain resampling algorithms might be naive or plain ignorant about how to resample images with potentially transparent pixels. Should transparent pixels not count to the final pixel? Should all pixels be averaged? Should the output pixel be the median or mode value? If the image is being resampled to 1/3 its size the resampling can be very cheap if only the middle of the 3x3 pixel cluster is selected as the output value.
[0] https://scholar.google.com/citations?user=GWB114EAAAAJ&hl=en...
Insurance company A needs to help with a wide variety of prescription needs -- cholesterol management, heart disease, kidney disease, cancers, MS, diabetes. Insurance company A negotiates with pharmaceutical companies B, C, and D for how much A will pay for any drug and what copay A will charge to the insured patient.
Pharma B makes a deal to ensure that their diabetes drugs are on tier 1 or preferred status (most likely to be approved/used/paid) in exchange for a very good deal to the insurance companies on the price for each prescription and a lower tier for their cholesterol drug. The agreement also states that all other diabetes drugs (insulin, let's say) will be tier 3 or need prior authorization. This is a contract that might last a year or 5 and is not public.
Company C makes a deal to get their MS drug as the only reasonably priced option in exchange for basically giving away their foot fungus drug. The insurance company is happy because every foot fungus prescription is pure profit. Company C is happy because they are they only game in town for MS treatments on that insurance provider.
Pharma D wants to get their insulin at a higher tier so that patients can afford it and not buy out of pocket. But Pharma B already has an agreement that all other insulins will be tier 3 or lower, so Pharma D is locked out of that insurance company.
The current health insurance and prescription system in the US __heavily__ favors large pharma companies that can negotiate on multiple grounds and leverage competing health interests. Small pharmas that offer a singular stellar product have a tremendous fight to even get past prior authorization.
The lung cancer concerns come from the only previous inhaled insulin Exhubra, which was literally vaporized insulin solution and offered no pharmacological benefit over injected insulin. The two instances of lung cancer in the 12(?) years of Afrezza testing occurred with patients who were smokers.
I'm not saying that Afrezza is the greatest invention ever, but it is a substantial step up from other mealtime insulins in my opinion.
Diabetes is a disease that needs its symptoms to be monitored and managed at a high granularity. Both monitoring and managing blood glucose can be really invasive though, with needles and finger-sticks causing extensive scar tissue development. Minimally invasive glucose monitoring technology that generates high-resolution time series data (such as Dexcom systems) literally transforms the way that people can manage their disease. Going from glucose reading every 6 hours (test strips) to every 5 minutes (CGM) is life changing. Monitoring that is non-invasive is the next technological step.
The holy grail for treating diabetes should actually be stabilized monomeric human insulin. Afrezza[0] is exactly that, and inhalable no less. The company that makes it just can't break through the insulin cartels and insurance-pharma exclusivity, so they are having a hard time. They did what was unachievable for 100 years though, and they are amazing chemists.
Let's say I am a photographer and I want to create or share some image galleries. Each image is big, about 10 MB and there may be hundreds of these images (less than 1000). They have a very permissible license, and I want them downloaded and used as wallpapers, for instance. I want the webpage traffic on my site (over flickr) because I want to drum up business and recognition for myself, but I don't want to risk my site going down under hug of death situations. Low cost solutions are ideal because this is a side project.
Is it best to host the main site on a single server (DO droplet) and kick the heavy lifting of image transfer to someone like imgur? What is the cheap and robust solution to this sort of problem?
I would love to see the Internet Archive put some muscle behind saving all the wonderful content on soundcloud.
>Design wise there’s nothing spectacular on show here. It’s almost but not quite ‘generic laptop’ but that’s fine.
>There was a point where I was considering digging out a mouse to help drive the OS.
If you can take away the need for millions of dollars to run a campaign then policy makers aren't beholden to the few wealthy supporters that helped get them elected.
They help connect volunteers to projects that range from building an open-source voter database to an Uber-like app that helps the mobility-limited get transportation to vote. They are extremely transparent and always interested in growing the network. Many members of the network are engineers, product managers, or independent coders.
Coordinated naked shorting attacks are real and legal. Flood the market with false shares and tiny lots of low-asks. Rapidly drop the price down to capture the easy stop-losses that retail investors might set. It is fool-proof because you know those shares can be obtained at a certain price (hedge-funds and market-makers can see the stop-losses). As soon as you acquire the stop-loss shares, pull off the selling pressure and use the shares just obtained to fulfill the short-contract. There is no borrowing.
[0]https://www.deepcapture.com/2015/07/goldman-sachs-internal-m...
If you can take away the need for millions of dollars to run a campaign then policy makers aren't beholden to the few wealthy supporters that helped get them elected.
They help connect volunteers to projects that range from building an open-source voter database to an Uber-like app that helps the mobility-limited get transportation to vote.