markus92

AZ hasn't submitted the paperwork yet and doesn't seem to be in a rush doing that. EMA has said they can do the approval within 3 days or so after receiving the paperwork.

Overselling their production capacity by a lot, for one. The major protocol violations in their trials and the weird way they are handling it, are another.

Deep learning's going to love this.

Source on the UK using single dose vaccines? Afaik the only one is the J&J one of which not a single dose has been delivered to the UK so far.

From a public health perspective, it's not zero sum. One country fully vaccinated and another equally sized country not vaccinated, leads to higher strain on the healthcare system than both countries 50% vaccinated. Pareto principle applies to hospitalizations.

A ton got exported in early January, although precise numbers don't seem to be public.

Halix is an independent contractor, AZ is not the owner at all.

For one, AZ doesn’t use the pre-fusion stabilized spike protein in their vector, while the mRNA and J&J vaccines do.

Typically caught in animal trials even, and surely something that would've been caught already with the amount of people already vaccinated.

Also owner of some of the most-shorted stock out there.

Same. Had to pirate my own paper once as my institution didn't have a subscription to that specific journal. Zero qualms here about that.

Yeah and so is Ferrari. Wouldn't call them a Dutch company.

No, they don't.

That's not true, ESTAs are being approved as usual.

Netherlands here, I routinely get them back within 8 hours after taking the swab. At work (hospital), we can get them within an hour if it's urgent.

That's true, on the other hand, consider that Moderna has lowered storage requirements twice in the past four months. This gives us three options, Is it Moderna taking more risks, Pfizer being more risk-averse or is the Moderna one inherently more stable?

Pfizer is spending a considerable amount of money on their cold chain, for example buying up pretty much all ultra-low temperature freezers they can find. I personally doubt they'd still be spending that money if they needed it, there's been plenty of time for a stability analysis by now.

Dutchie here, most of my colleagues do.

My experience with word documents with large number of cross references (think 500+), is that after some time they tend to get 'corrupt' and just don't work correctly anymore. At an old job where we prepared teaching material, we went through the effort of converting all of our materials (1000+ pages) to Latex just because of the lost productivity.

Education = Enterprise edition for all practical purposes, so they wouldn't have to pay.

He's talking about AF447, which involved an Airbus.

I understand what OP meant, but the data we currently have shows that one shot of this vaccine is not likely to convey a decent amount of protection.

The phase 3 only did two shots. Afaik the only one shot vaccine in phase 3 trials is the J&J one.

Looking at the phase 1/2 results, the booster shot seems to help a lot in getting the antibody levels up. See Figure 4 of their paper, https://www.nejm.org/doi/full/10.1056/NEJMoa2027906

In this case, Avidemux has a wonderful macOS port.

It happened, but it is not even close to what COVID does. During influenza season, the hospital I work at sometimes cancel elective procedures if it's a particularly bad year for influenza. Luckily influenza season has an end date. With COVID, we hardly even had any capacity left for oncology, the last thing we might cancel. Luckily the lockdown effects happened just in time before we had to take drastic measures there. This was not just a local problem, as patients here are centrally spread over all hospitals in the country.

That's the real problem with the disease, not only the fatality rate and long-term effects, but how quickly and severely it can bring a hospital system and all associated healthcare to its knees.

Sensitivity and dynamic range of the human eye is far, far better than any camera sensor you can buy at a reasonable price.

Also stop using locale settings for importing CSVs, or at least make a setting for it. I had to change my PC's locale to English (US) just to decently import CSV files in Excel

You mean healthcare, roads, education and social security for when I lose my job due to COVID? Taxes are nothing new and have always been like that.

I'm sorry to hear that about your wife and wish her all the best. As I'm not a medical professional and don't know your wife's exact situation, I'd say it'd be best to bring it up with your wife's oncologist that you'd like to give it a shot. I doubt they'd object for trying it for a cycle or two, but they know best.

That's absolutely right and it's a major problem of this study. There is one caveat though, in the most common ER+ breast cancer, radiological response is more predictive of survival than pCR. And in this study, they do observe a better radiological response in the fasting group, even when looking at ITT (though just barely significant).