markus92

That could very well be a possibility and something that researchers need to address if they wish to investigate this effect a bit further. We can make some educated guesses based on the supplemental table 3. Looking at the staging, grading, tumortype and the hormone receptor status, there don't seem to be any significant differences between the compliant and non-compliant groups. We know that those are the most important factors in assessing how aggressive a breast tumor is, with distinct treatment options and overall survival. So based on this information, I'm inclined to say the cause/effect is not reversed.

Of course, there could be some factors determining aggressiveness and response to chemotherapy that we do not know yet. Unfortunately I'm not in regular patient contact so can't say a whole lot about typical side effect profiles of chemotherapy, but I've heard some anecdotal evidence that for patients treated with immunotherapy, the more severe the side effects, the better the response.

Unfortunately that is far outside my expertise. The study here used a diet that is supposed to mimick the effects of fasting by having a low calorie/protein diet. In the discussion, they say the effects on a growth factor can be measured in blood plasma after 48 hours of fasting, or 48 hours of this diet.

My layman guess is that the best schedule is probably the one you can adhere to.

The title saying it's a multi-centre phase 2 trial makes it extremely clear. You don't do those in animals.

Interesting study with, as always, a lot of caveats. The most we can take from this is that it's worth to study more, the effect is existing but not extreme.

I don't get the submitted title here claiming that it protects from side effects. The study does not mention this at all, just that the side effects are similar despite omission of dexamethason in the fasting arm of the trial - it increases appetite, so makes sense to omit it if you want any reasonable compliance rate.

As with any fasting and dieting study, compliance is moderate at best. In this study, only 33% of patients were compliant for at least 4 cycles of chemotherapy, out of 12 cycles total. Most of them were compliant with at least once cycle though.

Overall, we need some more research on this in a larger trial. This paper is a call for funders to do just that - the trial ended prematurely due to needing to include more patients but there was a lack of funding to do so.

I'm currently doing research on a similar patient population, so open to answer any questions.

Have you clicked on the link? It's a result from an RCT in women with locally advanced breast cancer.

Even most blue collar workers I know have bought a house, what are you talking about.

It's common enough many American backpackers in hostels introduce themselves as Canadians, saves them the hassle.

Yeah, pretty much.

Assuming you're Dutch, but in the context of this article, HBO is college as well (the very clear distinction between applied universities and research universities doesn't exist in the Americas).

Transmeta hired him, he moved, he liked it and stayed.

I thought Python was designed at the CWI in Amsterdam. At least that's what Guido's linkedin says.

They’re antibody tests, those are extremely quick.

PCR test can be done in a few hours at most. It’s mostly the whole logistical problem that takes time.

They’re not done well in slack if you’re not looking for them! The default reply in a channel is not in a thread, so you get people replying inside the thread and outside at the same time. Makes them feel pointless.

$15 is a tad bit much for repackaged open-source imho.

We use Singularity as our container provider for the exact same reason. For now it has worked great and driver/CUDA updates haven't broken any containers yet over the past 2 years.

Something good about Singularity (which I bet you could also do with Docker) is that it automatically binds the right NVIDIA stuff into the container. It also works fine unprivileged :)

Cops don't have to make flight hours, fighter pilots do.

AA already laid off 30% of their management jobs, tho officially only starting October 1st.

They show these kind of things in freshman's week don't they?

You got a source for that or some other reading material? Never witnessed it myself so just curious.

They do have ultrasound (12 sensors they claim), but that doesn't help for detecting static objects iirc.

Yeah for example the Surface Pro X. It seems to be an amazing device but it needs a bit more software.

Weren't these devices utterly broken because the private RSA key was actually refactored? Or is this a different type.

There's some wonderful software for these calculators out there. Even a functional Gameboy emulator exists, used it to play Pokemon during math classes back in the days!

You lose the whole network/community effect. I'm not going to pay $60 a year to stick it to my mate who can't stick it back to me when he beats my record. It's their one feature that sets them apart from the rest and they just killed it.

Afaik Strava is more used by cyclists which is a more expensive sport. Everyone who is sort of serious uses it.

Cyclists are going to revolt, everyone wants to beat their friends on their favorite hill. It was one of the features I loved most about the app as I could see myself improving compared to people I have a good reference to.

Not sure what’s so special about this Döner, but shouldn’t take more than a minute for someone experienced in it. At peak hours, they can surely sell more than 12/person/hour.

So yeah, completely agreeing with you that the labor cost seems a bit inflated.

If you need to put 8 bars in your quick speedy bike? Absolutely.

For a simple urban commuter bike? No difference, you aren’t going to put in more than 3,5 bars in those fat tires anyways.

What I think is telling, is how easy to read Shannon’s paper is. Even today it is used pretty much as is at many EE colleges to teach communication theory.

Another cool fact: Shannon’s master thesis is most likely the most influential one of all time: in it, he linked Boolean algebra to electrical circuits with switches, essentially inventing digital circuit theory.

There's plenty of adult stuff sold on Amazon yet I still would like to sell my new line of e-books there.