1,070 karma · joined July 2, 2009
- performance. Obviously that depends on the circumstances but if you are working on a function that is used in many places you don't know the circumstances.
- error handling and reporting. Are you going to capture stderr from mkdir? If this fails can you provide a clear indication of the problem to the caller?
- paths. If you run mkdir without specifying an absolute path your program may fail if $path is not what you expect. That can also be a vulnerability.
- dependencies. Now you won't run in a distroless container or other cut down environment
- you lose type safety
Not saying "never shell out" but I've been burned by most of these so I am cautious about it.
Will this article disprove the rule that whenever the headline is a question, the answer is always no?
Also no.
We don't need humans to record something in writing. Evidence from physical processes can be used to infer historical climate and temperature, see https://en.wikipedia.org/wiki/Paleothermometer as a starting point.
I don't have time or expertise to evaluate, let alone conduct, clinical trial methodologies or meta-analyses, so I have to rely on secondary sources. The institutional consensus (from WHO, etc) is that the treatment is unproven, and further research is required. https://www.who.int/news-room/feature-stories/detail/who-adv...
It is apparent that there is a community (ivmmeta, BIRD, FLCCC) who strongly disagree and believe that ivermectin efficacy is already proven.
So the question becomes: who to believe?
We definitely have historical examples of astroturfing, regulatory capture, etc occurring - such as oil companies going to enormous lengths to muddy the science around climate change. And we also have recent examples (HCQ is the obvious one) where a large number of people became very excited about a treatment which has, I think, been fairly conclusively shown to be ineffective.
I have no magic method to determine which of these is the case this time, but my money is on IVM being a washout after further research.
I am skeptical of the BIRD folks, because they are acting and talking like a pressure group, not an open-minded body. I frankly doubt their impartiality when evaluating the evidence - I'm not alleging a nefarious purpose, just the omnipresent danger of becoming too attached to your pet hypothesis. To paraphrase your statement, I hope the truth on ivermectin comes out. And I hope it is an effective treatment. But these are two separate hopes.
BTW: You're providing an example here of how, once you start looking at a particular issue with a conspiracy mindset, you can easily construct an impervious epistemic bubble. The large trials cannot be trusted because they have been designed to fail; shadowy forces lie behind the doubts cast on the Elgazzar trial; and so on. This is not to say that conspiracies never exist. But it is worth asking yourself: what could I learn at this point which would change my mind?
https://twitter.com/GidMK/status/1416290819565244424?s=20
I'm no statistician, and am left rather unsure what to think.
And without wishing to be unkind, the fact that you are adverse to this phrasing is not of general interest, which is likely why you're attracting downvotes.
Not that this difficulty means we shouldn't try.
It parsed a string containing the timestamp and "08" or "09" was interpreted as an invalid octal number. Argh.