nyx

Stage IIIC NSCLC, specifically a superior sulcus tumor, advanced enough to be considered inoperable. Standard of care in this case was induction radiotherapy, followed by a single course of combination chemotherapy consisting of carboplatin, pemetrexed, and pembrolizumab (the last of which is the cutting-edge immunotherapy I'm talking about; brand name Keytruda.) After that, patients are prescribed the pemetrexed and immunotherapy alone for a long 2-year "maintenance" course, at which point treatment options will be reassessed.

Surgery was not an option here because of the size and location of the mass, but after the initial course of chemo a PET-CT showed an 80% reduction in size. After some time on pembrolizumab, symptoms continue to improve and surgery may be back on the table soon.

(edited for a more accurate picture of maintenance treatment; thanks to borbulon for refreshing my memory)

It really is remarkable how far cancer treatment has progressed, even in the last few years. I'm one of the unfortunate people who, through a close family encounter with cancer, knows more about this stuff than anyone should have to. The oncologist told my relative that if they had presented with this particular cancer just a decade ago, his recommendation would have been to start hospice care.

However, in recent years, a very effective checkpoint inhibitor immunotherapy has been developed for the cancer in question. ~2x the success rates of traditional chemo, greatly increased overall survival statistics, and with massively reduced side effects. The results speak for themselves: this drug has granted my relative years of extra life in the worst case, and a path to a deep, long remission in the best case.

I think that as the technology develops, by 2040 we'll be looking back at the present state of the art with the same incredulity that we currently have for, like, bloodletting with leeches in the Middle Ages. I think they've been saying this for a long time now, but it's truer than ever that a real cure for cancer is right around the corner.

That one looks good, pity it's an iOS exclusive.

Been using FatSecret[0] myself on and off for the past few years. Name is terrible, and over time it's slowly been becoming more of a featurespam bilkfest, but for the time being it's still perfectly usable without handing over a subscription fee or whatever.

[0]: https://play.google.com/store/apps/details?id=com.fatsecret....

Michael Davis, comedy juggling act: "They say a comic says funny things, but a comedian says things funny. This makes me a juggler."

https://www.youtube.com/watch?v=XKRrfAzdpW8

Actually, the robot in the video appears to retail for US$2700: https://shop.unitree.com/products/unitreeyushutechnologydog-...

You could probably build two of these, small arms included, for that 10K GBP (if you did it on the cheap).

"Sorry, we can't be friends anymore, you use bad software." Look, I guess I kind of get what you're saying, but unless you're Stallman this kind of lifestyle just isn't viable. Real people just want to use the thing that's easy to set up, good enough for their uses, and most importantly already popular. Network effects are a real showstopper for those of us who'd like to move to FOSS alternatives, and when the options are to either use the popular thing and communicate with our friends, or insist on the FOSS thing and isolate ourselves, it takes more zealotry than most of us can muster to commit to the latter.

Gab's userbase is described as far right in the lede of its Wikipedia article[0], which goes on to justify that descriptor by describing the types of views (neo-Nazism, white nationalism, antisemitism, QAnon, et al.) that can commonly be found there. Among the sources cited there is Fox News[1], which describes it as "known for attracting a far-right audience."

To my understanding, Fox News is pretty commonly accepted as a news source that's right of center, and even they've run articles describing Gab as far right.

I know it's uncool to do political bikeshedding on HN, but if you'll indulge my curiosity for a minute, how would you describe Gab's politics if not "far right," and are there any spaces you would personally label that way?

[0] https://en.wikipedia.org/wiki/Gab_(social_network)

[1] https://www.foxnews.com/politics/social-media-platform-gabs-...

I've given this problem a lot of thought, particularly the notion of cataloging recipes in some machine-parseable format and using them to either generate shopping lists or suggest meals based on pantry contents.

I think it's a non-trivial problem. Even with a relatively limited set of go-to dishes and ingredients, it seems to me like the data entry alone would be a herculean effort: making sure everything is normalized, operations like chop vs. mince vs. dice are standardized, etc. Currently, I'm relying on my fragile meat brain and a folder full of text files, skimming a directory listing of the folder for inspiration, and using individual recipes to build shopping lists.

I totally agree with the premise of the original article, that you can reduce recipes to trees and describe them with a formal language, but once I take off my computer scientist hat and look at this behavior critically, it seems horrifically asinine.

Anyone have a better solution? I know there are a couple of open ones out there, and I'm sure some of you nerds have homegrown something way more sophisticated. I've also got a hunch that this would be a great problem to throw language models at...

I'm relatively new to the industry, so this is the first recession I've been around for, but I've been noticing some patterns in the public layoff announcements I've read.

One thing that seems popular is a mass notification that says "hey everyone, layoffs are coming, we'll notify each of you individually whether you're affected or not." I suppose you could do the in-person meetings after that, and that might be okay for a small shop like yours, but it also seems like it might drag things out? I wouldn't want to be sitting around wondering if I'm going to be the next person called into the HR office.

Enrique Peñalosa, Colombian politician and past mayor of Bogota, put it well: "An advanced city is not one where the poor can get around by car, but one where even the rich use public transportation."

Crime on public transit doesn't mean public transit is bad, it means that public transit is a last-resort option patronized by the most desperate members of society. If our cities were designed for more convenient public transit, more people would be willing to take the bus, and your average patron would be less likely to be one of the scaries that you and your visiting friend were worried about.

Well, this is stupid and darkly hilarious. I'm only slightly ashamed to admit I created something similar, albeit much less sophisticated, several years ago.

Before Reddit started worrying about advertiser friendliness and cleaned up its act, there was a thriving network of hate subreddits. Probably a lot of overlap with the /pol/ population, based on the amount of overt, disgusting racism to be found there.

Anyway, I wrote some crappy Python that would go visit my carefully curated list of racist cesspool subreddits, hoover up all the post and comment text, and add it to the corpus, then some more crappy Python that would ingest the corpus and do Markov chain stuff to spit out some fairly convincing internet hate speech. I think the key to my success was that frothing racists in comment threads typically aren't putting forward the most cogent arguments anyway, so it's a pretty low bar.

I didn't post this little project or write it up anywhere, because I felt bad enough having brought it into the world, but it was good for a chuckle, at least for a little while.

I've used both, though not for anything especially complicated. Your guess about the polish level is correct; ESXi blows Proxmox out of the water interface-wise, especially for some specific tasks like configuring networks or managing PCI passthrough devices. As far as "more limited" goes, I can't say I noticed much of a feature discrepancy, although being open and just sitting atop KVM, Proxmox doesn't have any of the artificial limitations imposed by VMware (like a cap on number of vCPUs in the free version, eugh).

One pretty big one, if you're looking at homelab use, is that Proxmox is just Debian, so it's waaaay more likely to run on crap-tier commodity hardware, whereas VMware has all the usual enterprise-level support commitments and so you're very much on your own if you try to force it to run on hardware that isn't on their official compatibility list.

The title suggests it's going to be a cool ecomodernist story about efficient agricultural use of land, and it turns out it's a luxury strawberry grower selling berries a dozen at a time for $2 each in a giant plastic tray. Ick.

Yep, Discord has been a hunting ground for child predators since it got popular as a chat system for gamers (many of whom are children). This has been a problem since long before a certain American political faction started throwing the word "grooming" around to mean "not heteronormative," and in my opinion it's probably best to avoid legitimizing that rhetoric by responding to it.

Many of us would argue that providing privacy-invasion-as-a-service, at scale, to people who want to sell us shit is harmful and villainous. Even if you set aside the dangerous aspects of some of the "free online services", like YouTube serving as a massive engagement-driven platform for propaganda and radicalization, you're still left with web services designed to hoover up all your data and sell your eyeballs to businesses. That is the behavior of a hostile actor, and vast swaths of people accepting this tradeoff doesn't make its existence any less objectionable to some of us.

Do marketers care whether their marketing is intellectually honest? Maybe that matters if the people you're marketing to are very discerning or cynical, but I'm not sure I'd put the typical Apple customer in that bucket. As long as the marketing gets people to consume the product, I don't think it matters if it's stupid or if it's lies.

My guess is that people who work for Apple do it more because of the giant FAANG salary and the social cachet than because of the product marketing.

> The only way you can make such a significant shift is by saying from a particular date, you won't be able to buy a new gas boiler."

Or... subsidize the installation of new heat pumps via tax credits or whatever mechanism makes sense in the UK?

The whole "big bad out-of-touch government wants to take away your Thing That's Perfectly Fine and force you to do Wasteful Extravagant Spending instead" headline is pretty obvious outrage-bait (which makes sense given the piece's provenance), but the article itself is also pretty light on supporting details... imagine that.

Entertaining read. Some of it is clearly before my time, and some of it is timeless, I think. Was kind of amused when I got to the section on avoiding detection, specifically this bullet:

* I would keep in mind that the numbers I dialed on my phone could eventually be used to track me again. For example, if I called my girl friend frequently, after I changed numbers and location I might still be calling that number. The telcos now have toll record data base software that can cross reference and track this type of thing.

Very turn-of-the-millennium that this very basic mass-surveillance capability was even worth mentioning. Apparently the author died in 2010, pre-Snowden. Things have certainly changed.

(2005)

Not exactly the same question, but I think this fictional Wikipedia article is persuasive on this sort of topic: https://qntm.org/mmacevedo Won't spoil it, but it's definitely worth a read.

Most people get baked, wonder if we're alone in the universe, and take a nap. Astrophysicists get baked, wonder if we're alone in the universe, and publish papers like this.

Jokes aside, is there really any practical value in this sort of research, or is it the kind of thing that we do because it's interesting and kinda cool? Don't get me wrong, I think it's valuable for that alone, but...

The thing that stands out the most to me here is the constant drumbeat blaming the "regulators", as if the only thing keeping their buggy, shitty murdercars from going fully autonomous is those backwards gummermint bureaucrats.

I'd be willing to bet Elon huffs enough of his own farts that he too genuinely believes this, but I can definitely see the "real-life Tony Stark!!!111" fanboy cohort lapping that right up. The Venn diagram between Elon Musk fans and borderline-ancap laissez-faire extremists is practically a circle.

This article is a lengthy preamble to an advertisement for a SaaS product, but I'm thankful you at least get to a conclusion before the evangelism begins: there's a basic pattern here, i.e. "get data from X, transform it, and put it in Y", and the tools, systems, and platforms listed are all solutions to the same basic problem.

I'm sure there's a use case and a market for this product, but I'd wager that I'm not alone among the HN audience in thinking that I'd rather have a couple shell scripts in a Docker container on my own hardware or whatever than spend a bunch of money irreversibly trapping my automations in some proprietary cloud-hosted thing where they can be held ransom come the renewal date.

I've been following this company for a while now, and others like it, and I'm really wondering how the economics of these rent-a-big-GPU services shake out. The specs say you get a GeForce GTX 1080 (or equivalent, so maybe they're licensing NVIDIA vGPUs or something)... do they actually have one big GPU per subscription, or do I just have access to a big GPU whenever I want? You can't slice up a GPU as effectively as you can slice up CPU cores... Filling up a datacenter with big GPUs seems like a very expensive proposition.

I haven't thought about Clover in forever, but didn't it add tabs to your existing Explorer, versus being an Explorer clone plus tabs? The behavior required for the former probably looks a lot like malware to a heuristic detection engine.

I've visited Bruce and his home as well, and it's almost startling how welcoming he is. When I went, it was the middle of a nice afternoon, and so he already happened to be outside conversing with some other guests, but if you poke around on his website, you'll find that he essentially says "if you come for a visit and I'm not around, climb up on the wing and come bang on my airplane until you wake me up."

Was only there for a few minutes, but we got in a short and pleasant conversation about housing scarcity and the future of AI. Really interesting character, clearly living his best life.

This is such a sleazy game to play, and it looks to be getting more popular as corporations realize the average consumer just accepts it. Zero Motorcycles, the longest-standing electric motorcycle manufacturer, has announced for their 2022 flagship models that things like battery capacity and charge rate will be gated behind one-time in-app purchases, which is mind-boggling. Having to lug around batteries you can't charge to full capacity on a bike, where space and weight are at a premium, actually makes the product worse if you don't pay the rent. Hoping this strategy blows up in their face, but all indications suggest it's going to be lucrative and the angry minority will just have to eat it.

I, uh... should preface this by saying that vim is my main editor, and I always install a vim plugin if possible when using a different one. It's great, it makes me faster, etc. etc.

Alright, that aside, when all is said and done I think a lot of people just want to edit their file. Parent comment about having to go to Google to do simple things makes a good point, and the response that "actually, I think having to read a bunch of troglodytes arguing with each other on Stack Overflow is an important part of the experience" is the kind of thing that makes it hard for everyone else to take vim fanatics seriously.

The progress bar is neat, and it's impressive what modern fonts are capable of and everything... but I'm personally not a fan of ligatures in code fonts. Not sure I can articulate why, but it just feels like we should draw the line at our fonts causing fundamentally different glyphs to be displayed in our editors (e.g. ≤ instead of <=).

Surely this comes down to preference. Does anyone who uses Fira like those ligatures?

I think that's a fine way to characterize nostalgia, but it seems like a needlessly reductive, even perhaps dismissive, way to respond to the author's point of view. I think there are plenty of reasons to dislike the direction the Web has taken since its inception, and many of them are more substantial than just nostalgia for times past.