radus

Details on the 20 minutes of easy mods?

"Open in browser", maybe?

This is my experience in my slice of biology as well.

Based on my infrequent use of IRC, I am not interested in investing in learning the tools - which by the way change quite a bit over a few decades.

On the other hand, the same usage pattern with other chat apps such as Zulip/Slack/Mattermost and others requires no specialized knowledge.

irccloud.com looks great, except for the fact that you have to pay if you don't want to be kicked off after 2 hours of inactivity.

My experiences as an infrequent IRC user over many years:

- hmm, I have to download a client? maybe I can access a web interface?

- okay, I have this connection string/url

- how do I join a channel?

- how do I set my nickname? is this persistent?

- oh someone else is using my name? is this for the channel or the server??

- what's the etiquette of this particular channel? (I realize this is probably the case for any chat, but it seems like etiquette is much more vaunted in IRC)

vs. zulip

- enter url in browser

- login with my github credentials

.... that's it

Okay, I did it.

    import subprocess
    import re
    import yaml

    output = subprocess.check_output(['ls', '-l'], universal_newlines=True)
    matching_lines = []

    for line in output.splitlines():
        if re.search(r'total', line):
            matching_lines.append(line)

    with open('matching_lines.yaml', 'w') as f:
        f.write(yaml.dump(matching_lines))

Python 3.7: https://repl.it/repls/PotableDamagedAutocad

Python 2.7: https://repl.it/repls/OrchidDirtyNotification

The bulk of the linked page talks about aspects of Windows 10 other than telemetry.

If Windows 11 boots up with a progress bar that says "uploading data to MS for mindcrime verification", and requires me to play games and watch ads to pay for it, I will reconsider my OS choice. For now, I'm enjoying the OS and have dialed down the telemetry to a level that I am comfortable with.

Counter-anecdote: I'm the happiest I've ever been with Windows both as a development platform and for everyday use. The release of WSL has solved a lot of daily annoyances, and I'm hoping that the new Windows Terminal app will soon be usable so I can replace cmder which has been great, but a little clunky and slow in my experience.

Other new features that I enjoy: Windows Sandbox, new Snip and Sketch, the current iteration of OneDrive (though I think I still prefer SkyDrive from many years ago..), Your Phone app for sending messages, emoji keyboard, clipboard history, local PIN instead of password.. I could go on but those are all things I use on a frequent basis and they make for a great experience.

Good news - San Diego is well on its way to extending the trolley system from downtown to UTC.

You're probably not aware of the fact that San Diego is in the process of building a tram system that is very promising. If you drive along the route like I do, you can see progress every day - it's a huge project and I'm extremely happy to hear that they're pairing it with legislation that will increase it's positive benefits.

I'll take a tram project that is being implemented ahead of schedule over the promise of automated cars which are always seemingly around the corner.

Isn't https over the hump in most of the world?

This is a very half-baked idea, but perhaps a compromise would be to make the text content free to access and reserve PDF downloads for subscribers or paying customers. Ideally the content would be presented through something like eLife's Lens project. [1]

[1]: https://github.com/elifesciences/lens

Could you elaborate?

There are definitely many images and graphics. I don't know if my sample is representative of most literature, but I don't think it's too far off..

A recent paper seems to have solved this issue by doing away with the terminal amine and sulfate groups.

http://www.jbc.org/content/293/5/1517.full

Sidebar: I've spent way too much time reading about this compound and its target..

I think that's a bit of a harsh dismissal. It's a sterol natural product that binds to PTPN1 allosterically. I've scanned the literature a bit and it seems reasonably well validated. It's termed as selective in many papers, but this is primarily referring to selectivity over a PTPN1 homolog, something which previous compounds had had trouble with.

That's a great sign, and a really nice target to choose to develop. This doesn't mean that it will be safe in another patient population (though it'll probably be okay), nor do these animal studies guarantee efficacy in humans. Humans have very different regenerative potentials compared to mice or zebrafish, or a more extreme example: axolotl. Additionally, drugs that target regeneration must walk a fine line between regenerating damaged tissue and overstimulating growth pathways (cancer).

It's mostly composed of PDFs actually. Judging from my own library the average publication is about 2 MB, and I believe about 1e8 publications are currently indexed, so it's on the order of hundreds of TB.

Relevant study in zebrafish/mice with this compound (MSI-1436, aka trodusquemine): https://www.nature.com/articles/s41536-017-0008-1.

How do you determine those percentages? The reason all these studies are necessary is because biology is hard.

Example: cancers where Ras proteins are mutated are common and also predictive of poorer outcomes. Ras signals through several effector pathways including ones involving BRAF. So if someone develops a BRAF inhibitor, we should call it a day and people should just start taking these? Ooops, turns out this paradoxically enhances Ras oncogenic signaling.. Is it better to find that out 6 months when everyone who's taken these dies, or would these people be better served by doing your beta testing and "years of studies/paperwork" in cancer cell lines and mice?

Thing is, that really isn't much of a problem in downtown SD where most of these cameras are.

Here's a mumble web client: https://github.com/Johni0702/mumble-web

I do this as well. And you can save svg files from matplotlib for editing or composition in Inkscape!

According to the article, you may be getting more hair and be less susceptible to sun damaged skin. What isn't clear is whether or not taking melatonin orally at typical dosage (300 mcg to 5 mg) will have those effects in humans. It seems that most of those human studies used topical application, and several of the animal studies used melatonin implants. Also, here is a quote from one of the references (Kleszczynski and Fischer, 2012):

> Regarding clinical application, exogenous melatonin should rather be used topically than orally, since orally administered melatonin appears in rather low levels in the blood due to prominent first-pass degradation in the liver, thus limiting skin access. Topical application might be meaningful, since melatonin can penetrate into the stratum corneum and build there a depot due to its distinct lipophilic chemical structure. Therefore, endogenous intracutaneous melatonin production, together with topically applied exogenous melatonin or metabolites can be expected to represent one of the most potent antioxidative defense systems against UV-induced skin aging.

Sci-hub is not accessible from my institution.

I was also surprised by how harsh the comments are, but I suppose it mirrors the harshness of the academic world.

Unfortunately, I didn't really know I wanted one for myself and also for family until right now, especially at the $15 price point.

It seems like these are selling out in a lot of stores, but I wonder if it's smart to buy one when they'll probably no longer receive updates.

Not my experience with Docker on Windows - volume mounting works (and has worked) without issues. I remember at some point being prompted to share my drive so that Docker can access it - perhaps you need to flip this switch in the Docker settings?

I understand. I guess I was thinking about how Scuttlebutt works where you have multiple client apps (with radically different UIs) that can federate over a common protocol.

Is it possible to customize a Movim instance such that it behaves more like tumblr or a photo blog? As it stands it seems to be a lot of things that Tumblr was not, which is great, but perhaps this would be more attractive to Tumblr refugees if a pared down interface was available.