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refurb

27,659 karma · joined July 30, 2011

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refurb··on Felony charges for citizen deleting phone data at US Border
> Destroying evidence assumes he is guilty of a crime which there be evidence of.

This is 100% untrue. You can be guilty of destroying evidence that includes no criminal activity whatsoever.

refurb··on CIA funding helped keep NeXT afloat in the 80s
If you think government geopolitical policy could be disrupted by a lack of pizza delivery i can assure you it’s not.
refurb··on Universal health coverage could save $1T and 114k lives a year: study
What hospitals makes has nothing to do with physician pay - those are separate categories. Hospitals aren’t going to magically start giving some of their profit to doctors to help cover their lower fees.

OP makes a good point. The studies assumes two diametrically opposed things will happen - doctors will take a 50% pay cut but access to primary care physicians will increase.

Why would we solve the primary care physician shortage by cutting their pay?

refurb··on People are worried about America's solvency
You need to adjust for inflation.

Also the correct measure is % of GDP

refurb··on People are worried about America's solvency
US government solvency is backed by the power to tax and tap into the massive US economy.

Considering the US has one of the lower overall tax rates of developed economies, I’m not sure we’ve reached any sort of crisis level

refurb··on Semaglutide linked to lower predicted dementia risk
I disagree on the “if you’re poor”. I find eating healthy cheaper.

You can prepare healthy meals from basic and cheap foodstuffs like vegetables, whole grains and legumes, eggs, low cost meat cuts etc. You can prepare delicious meals for under $1 each.

Buying prepared unhealthy foods is what is expensive.

refurb··on The AI trade now runs on borrowed money, and the lenders are repricing it
While the debt numbers might look large, don't forget how much revenue is coming into these companies as well.

OpenAI gross revenue was $4B in 2024, $13B in 2025 and estimated to hit $26B in 2026. Revenue is doubling or more.

Same with Anthropic. $1B in 2024, $9B in 2025 and estimated to be $47B in 2026.

All the AI companies together are pulling in hundreds of billions of dollars per year in revenue and it's going up quickly. To me, taking on trillions in debt in order to make hundreds of billions in revenue doesn't seem crazy.

refurb··on The AI trade now runs on borrowed money, and the lenders are repricing it
I would question the idea that highly industry consolidated debt is competing with risk free debt issued by the US government. Those are two very different products.

And while the quarter by quarter growth may seem astonishing it very different saying “debt levels today are alarming” versus “if this trend continues debt levels will be alarming”

refurb··on The AI trade now runs on borrowed money, and the lenders are repricing it
By that measure it doesn’t sound like that much.

You’re talking about about an amount that is a 13% of the total US government spending, of which is 20% of the entire US GDP.

I’m not saying it’s insignificant but it’s only a few percent of the US GDP and it represents spending over several years.

refurb··on US citizen charged after GrapheneOS phone wipes during airport search
It sounds like you can’t grasp a discussion on another topic yet you insert yourself into it.
refurb··on US citizen charged after GrapheneOS phone wipes during airport search
It seems like your desperation to make a point has caused you to goal pole shift a second time!
refurb··on Glue bonds to nonstick surfaces and wipes clean with ethanol
DMF is quite different than acetone.

As a chemist it’s a highly polar, very high boiling point solvent that is the “go to” when you can’t find a solvent your reactants dissolve in.

Acetone is less polar, more chemically reactive and lower boiling point. It’s rarely used as a reaction solvent due to its reactivity, but it is common in crystallizations.

Both are quite non-toxic (your body makes small amounts of acetone!), but I recall a cancer risk with high exposures of DMF (the example was tannery workers who sprayed it without any safety gear and got soaked).

refurb··on US citizen charged after GrapheneOS phone wipes during airport search
As someone who immigrated to the US and has been detained in secondary inspection I can assure you I do have knowledge in this area.
refurb··on US citizen charged after GrapheneOS phone wipes during airport search
I mean the guy didn’t have proper documentation and admitted to illegally entering the US (not at a crossing I assume).

It’s a completely different situation.

refurb··on US citizen charged after GrapheneOS phone wipes during airport search
Maybe, but being detained for a couple hours is better than committing a felony, no?
refurb··on US citizen charged after GrapheneOS phone wipes during airport search
CBP doesn't need a warrant to search at the border, including electronic devices.

However, if Tunick was smart he would have refused to provide the PIN, and let them seize it. He'll get it back eventually, but it was in his right to refuse.

refurb··on US citizen charged after GrapheneOS phone wipes during airport search
A far better approach is for the US citizen to simply say "I chose not to provide my PIN".

The officer will say something like "That's your choice, but I will need to seize the device to conduct an analysis. It will be returned once the analysis is complete".

Then you shrug, and they will let you enter the US. The cops will try to get into the phone, fail, and return it to you.

Just bring a phone you don't mind losing for a few months.

refurb··on US citizen charged after GrapheneOS phone wipes during airport search
> It's people who couldn't get out of jury duty.

But that's good no? People who got out never would have taken it seriously.

I sat on a jury trial and was highly impressed with how seriously my fellow jurors took it - especially the presumption of innocence. When they started to go down some incorrect logical path, someone would step up and correct it.

Not to mention the public defender ripped apart the DA's case. It was the exact opposite of what I was expecting.

> Prosecutors have high success rates.

You're forgetting that the prosecutors don't bring cases they think they're going to lose to trial, they either drop the charges or try a plea deal. So you'd entirely expect the success rate to be high.

refurb··on US citizen charged after GrapheneOS phone wipes during airport search
>U.S. law though is highly non-autistic

LOL, that made me chuckle.

People somehow think they're the first one to think of a workaround to a law, when in fact it's been happening since the first law was written down. The law adjusted and if people think they can do one thing, then claim they intended another they have a big surprise coming.

refurb··on Clinical failure rates over the decades: yikes
Lots of examples of older drugs currently in use that are potent hERG inhibitors: haloperidol (antipsychotic), ketoconazole (antifungal), erythromycin (antibiotic), domperidone (anti-emetic), hydroxychloroquine (anti-malarial).

All of these are rather potent hERG inhibitors, yet were approved and widely used before that activity was discovered. Pulling them off the market would have been quite disruptive considering some of them are the only effective treatment for rather serious diseases.

Of course it's a matter of opinion, but I would argue some of these workhorse medications would have had their program killed by the manufacturer (fear the FDA won't approve) or the FDA itself (risk of fatal arrhythmias) if they were developed today.

Yet the risk is managed by flagging the contraindication when combined with other drugs (since the inhibition is often additive).

refurb··on Clinical failure rates over the decades: yikes
Look at the GLP-1s. Lilly spent tens hundreds of millions developing an oral version that was otherwise the same as the injectable’s.

And the notorious inhaled insulin that Pfizer launch (and horribly failed).

There are many ways to differentiate drugs, not just efficacy.

refurb··on Clinical failure rates over the decades: yikes
It’s a similar problem you see with all safety related decisions - as the large risks are eliminated you become more concerned about the smaller risks.

Plenty of successful drugs from the 50’s had hERG activity, yet the impact on safety was marginal. Today plenty of programs are killed over it.

Increase safety scrutiny does increase safety, but at a cost.

refurb··on Clinical failure rates over the decades: yikes
> Failed attempts cost society nearly nothing

The world does not have unlimited resources. Money spent on one project is money that can’t be spent on another.

refurb··on Clinical failure rates over the decades: yikes
As someone who used to work in pharmaceutical R&D, the important thing to remember is the hurdle to get over hasn’t remained constant.

The FDA has gotten significantly more strict in its review than it was in the 1960s.

A good example is hERG inhibition as an off-target effect. It’s a receptor on heart muscles and will result in QT prolongation and potential arrhythmias.

It wasn’t discovered until the 1990s. Now every molecule is screened and many are dumped. The impact can vary but there are tons of drugs on the market now that are hERG inhibitors (many discovered after the fact).

It’s a good example of the increased rigor that the FDA applies to everything they review that past trials never had to face.

refurb··on Couple pay >$800k for a gene-editing therapy for their daughter. She died.
Zolgensma acts on the peripheral motor neurons not the CNS
refurb··on Hacker wipes Romania's land registry database
The US title system varies by state. Some are deeds based others are Torrens (registry), though deeds based dominates.

And as for being screwed, that’s why real estate transactions have title insurance - to cover damages from incorrect titles.

refurb··on Why American ambulance rides are so expensive
Clarifying definition is not a "word game". You seem quite uncomfortable debating the facts, and that's ok.
refurb··on America pays workers just 27% of what its wealth allows – the worst in the OECD
Hmmm, this index scores US at 80% and Mexico at 86%.

To say the results are suspect is understating things.

refurb··on Why American ambulance rides are so expensive
I never said no one would be bankrupted by ambulance fees.

We’re talking about financial ruin of the government.

refurb··on SpaceX wants to launch 100k more Starlink satellites for 100x the bandwidth
Your article is about landlines AND they received government approval to end service.

We’re talking about remote areas of the US that have almost no local population.

Why would a company put a cell tower in the middle of federal land where no one is allowed to live?

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