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remote_phone

2,527 karma · joined May 24, 2018

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remote_phone··on Using paleogenomics to elucidate 10k years of immune system evolution
No because the immune system would have to know to rely on the fact that the markings are different across every single cell in the body. Until they were all exactly the same, the immune system couldn’t switch over to relying on this.

Entire organs not just cells would die. It needs changes in two separate systems, the cellular system and the immune system, and it has to occur randomly.

remote_phone··on The IAB loves tracking users but hates users tracking them
I use my name to differentiate different suppliers of my information. I have a spam-only email account but my name is what I use to differentiate between different companies because there’s no way they can filter that.
remote_phone··on Using paleogenomics to elucidate 10k years of immune system evolution
The immune system is one of the reasons why I stopped believing in large scale evolution. I still believe small scale evolution exists, but I do not believe that our immune system came about randomly.

There are two main factors to our immune system that protect us:

1) all our cells are marked uniquely and exactly the same across every cell in our body. Every human, and I think every animal, has this same feature where all cells are marked the same. But unless there was an immune system to enforce this, it has no value. If it were random you would expect every cell to be marked randomly but it’s not.

2) our immune system is designed to attack anything that isn’t marked with that unique identification. If we had random identification per cell, the immune system we have couldn’t be created.

This system couldn’t be designed separately. It’s essentially a single transaction two-step evolution that simply couldn’t have been done randomly at different points in time. If you created an immune system that attacked things that weren’t marked the cell across all cells, the organism would die because the immune system would attack itself the way transplant patients would. The immune system we have couldn’t be created unless all the cells were marked the same.

Both parts (unique identification are the same across all cells, and the immune system that attacks any other things that aren’t marked the same) must have been created at the same time.

If anyone has any counter arguments I would love to hear it because I’ve been thinking about this long and hard during Covid and couldn’t think of anything else.

remote_phone··on Wyoming senators want to phase out sales of EVs
Can we penalize sites that provide misleading headlines? I’m so sick of sites twisting the facts like this, if we could build a list of sites that don’t manipulate the facts and just present things straight I would love it.
remote_phone··on Ask HN: We found a cracked version of our software on the web, now what?
The first PC software I got back in the early 80s was a copy protection cracking program. I think there were 2, copywrite and copyiipc. Since then, the battle between copy protection and cracking has been going on.

You will never stop cracking. The only way is to convert the application to SaaS. Otherwise just try to minimize casual pirating and leave it at that.

remote_phone··on U.S. cancer death rate has dropped by a third since 1991
By the time my friends dad had pancreatic cancer detected, he died within 6 weeks. It’s also the fastest growing cancer in the US. Every time I read about someone dying of cancer quite often it’s pancreatic cancer and it terrifies me.
remote_phone··on U.S. cancer death rate has dropped by a third since 1991
What is your opinion on the Grail blood test?
remote_phone··on On the lack of progress reports from the Mill project (2022)
The project is dead, they spent all the money and there’s none left. The things the responder says is exactly what a con artist would say to keep stringing people along.
remote_phone··on Post-processing is ruining iPhone photos
Pros can use Halide. For me, the default iPhone camera app is pretty good in my opinion.
remote_phone··on College that fired prof for showing image of Muhammad could lose accreditation
They do as long as it’s not Christianity.
remote_phone··on Netflix has job with almost $1M listed salary range, to comply with new CA law
Previously Netflix only had 2 levels: software engineer and senior software engineer. I heard they were going to change that but I don’t know to what extent that was changed.
remote_phone··on Netflix has job with almost $1M listed salary range, to comply with new CA law
A lot of people responding on here don’t seem to understand that $900k/yr is a very real salary at Netflix. They pay top of the market and it’s all in cash.

The pressure is very real and lots of people get fired quickly (a PM I worked with said she saw over 20 engineers let go in the 2 years she was there) but I find that the ones that stay at Netflix for a long time love it and are never worried about being fired.

remote_phone··on Netflix has job with almost $1M listed salary range, to comply with new CA law
I know a couple of Netflix employees making over 700k cash. I also have a friend who was a recruiter at Netflix that handled an offer to an engineer for $1M cash. These are real numbers.
remote_phone··on Ask HN: Why did Frontend development explode in complexity?
Too many different platforms to support which causes engineering issues.

For web, you need to support multiple browsers and infinite number of screen sizes.

For mobile, you need to support iOS and android and multiple different OS versions and screen sizes.

You also want to minimize platform-specific code, which often causes you to roll your own way of doing things. From an engineering point of view you don’t want your code based to diverge, which would cause supportability issues and/or lengthen and complicate developing new features.

It’s basically a nightmare for any moderately successful company that doesn’t want to alienate any customers.

remote_phone··on Games people play with cash flow
You are repeating exactly what the article said.
remote_phone··on NY Sabotages Right to Repair Bill [video]
Who is on the regulatory body that reviews these cases? Probably friends of the airline industry.
remote_phone··on NY Sabotages Right to Repair Bill [video]
> Tickets are nonrefundable because otherwise the network doesn't work, financially.

This is 100% false. Southwest Airlines is one of the most profitable airlines in the US and their refund policy for refundable flights is a full refund up to 10 mins before the flight. For nonrefundable flights you get full credit if you cancel up to 10 mins before your flight, with no additional fees.

During the pandemic, ALL airlines moved to full credit with no change fees if you cancelled your flight. Previously they would have absurd $200 change fees or loss of your flight.

The idea that airlines can’t survive with flexible, consumer friendly policies is a lie. Things like the check in fees or fuel surcharge are pure profit.

remote_phone··on What happens when babies are left to cry it out?
You have no authority to say they are not comparable, nor do you have any authority to say that being a child gives you any insight on how to be a parent.
remote_phone··on TV Ratings Road Map: Where, When and How Viewers Watch in the Streaming Era
As soon as Netflix blocks my ability to share my account with my sibling, I’m cancelling my account and bittorrenting whatever I want to watch from there. I’m willing to pay fees that have practically doubled over the past few years but I’m not going to pay for 2 accounts when we generally don’t watch at the same time and I probably use Netflix once a week at most.
remote_phone··on When do we have a scientific fact?
This article is garbage. If we agreed that 95% consensus was “scientific fact” then plenty of “truths” that we knew back in the past would never be revisited. For example, homosexuality was thought of as a choice as recently as the 1980s. Or high fat diets caused heart disease. Or larger heads equals smarter people.

The reason why scientific facts don’t exist is because the truly great scientists before this author knew that facts are only as good until the next data point that disproves it.

On the other hand, trying to establish scientific fact as consensus will result in political fights to try to force the scientific community and policy makers into decisions that further their own agendas. The sex/gender political fight right now is a great example of how consensus can be forced to further agendas. It’s evil and should never be pursued. Leave science as it is.

remote_phone··on What happens when babies are left to cry it out?
Not even a single study was cited in that page. It’s garbage.
remote_phone··on What happens when babies are left to cry it out?
100% correct. The baby-rearing book industry is a fraud. They claim “well the average baby does X, Y, Z” but they don’t tell you that the standard deviation is huge. New mothers like my wife were stressed beyond belief because our kid only slept 10 hours and ate twice as much as other kids. She was convinced there was something wrong until I proved to her that he was within the standard deviation of normal.

Do what feels right for your child. No two children are the same, even twins. Infants are very resilient so don’t worry you’re going to scar or damage them. They generally won’t unless you are truly abusive.

remote_phone··on What happens when babies are left to cry it out?
What is easier, watching a movie or making a movie? Or do you think those are equal in effort?
remote_phone··on What happens when babies are left to cry it out?
The fact that you are getting enraged is a huge part of the problem. Keep your own morality to yourself and your own family. If you don’t want to use cry it out, then that’s your decision. The fact you project onto others is the problem and it’s none of your business.

Cry it out is effective and works wonders for families and it has no side effects, as mentioned in the article itself.

remote_phone··on What happens when babies are left to cry it out?
> Having read "The Boy Who was Raised as a Dog", which goes into a fair amount of detail regarding attachment and attachment disorders, letting an infant "cry it out" strikes me as child abuse.

You sound exactly like someone who doesn’t have kids, advising parents and speaking with authority that you don’t have.

remote_phone··on Hydroxychloroquine lowers Alzheimer's disease and related dementias risk
The use of ivermectin and hcq were started because doctors were trying to develop a protocol to help with treating Covid in 2020 and there was anecdotal evidence that it worked.
remote_phone··on Hydroxychloroquine lowers Alzheimer's disease and related dementias risk
False. We didn’t have a vaccine available until early 2021. People were scrambling to find a therapeutic way to treat Covid and there was anecdotal evidence that hcq and ivermectin might work. They wanted large scale trials but they were unscientifically denied which made people very suspicious about the reasons why.

Yes, they turned out to be ineffective but the reaction against them was mindblowingly biased and filled with propaganda.

remote_phone··on Waze tests new alerts warning drivers about roads with a ‘history of crashes’
Waze innovation died as soon as they were bought by Google. It’s really sad. Same thing happened with Nest.
remote_phone··on Ask HN: What to do with old computer books?
I throw them out all the time. I constantly buy new books and throw it older ones. If I donate them to libraries or goodwill I’m selfishly burdening them with useless books do I just throw them out myself.
remote_phone··on Ask HN: Managing Aging Parents Finances?
My mother died of dementia.

Let me tell you, it doesn’t get easier and it doesn’t get better. It only gets worse every day. Be prepared for an absolute shitshow. Dementia isn’t just forgetting stuff. It’s progressive brain damage that leads to things like them not being able to care for themselves, becoming incontinent and being unable to swallow. The financial situation is the least of your worries but also the greatest of your worries because there are no facilities that are affordable that let your dad live his last years of his life with dignity. If you haven’t already I suggest reading up on it and the effects that dementia had on their caretakers.

Are you the only one available to take care of him? Does he not have family around him to take care of him? He will not be able to survive on his own in a few years, if not already.

You need to get power of attorney over his finances. That means you control everything. Depending on where he is at, and what you can afford, he will need to be in medical care in a few years. It can either be in a memory facility with full care which is very expensive, or you can try taking care of him yourself but you will still need to hire a nurse to bathe him as he becomes incontinent, or brush his teeth, etc. If where you live has universal health care like Canada, you’ll find that it’s really not helpful and your own cheaper options are basically mental institutions that are horrible. But the waitlist is years long so you need to be prepared for this.

My absolute condolences to you, your dad and your family. Dementia is the cruelest diseases. If I find myself going down this path I will definitely commit suicide to relieve the burden from my family. In Canada they won’t let you end your life with medical assistance if you have dementia which is governmental stupidity to the extreme. If anything people with dementia need that option more than anyone because it will never get better.

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