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sbinthree

627 karma · joined August 17, 2017

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sbinthree··on Why mRNA vaccines could revolutionise medicine
Yes, and the formulation took 48 hours after covid was sequenced. This should be the last pandemic ever assuming brutally out of date regulatory bodies catch up.
sbinthree··on Let the ultra-rich and influential skip the line for Covid-19 vaccines?
The removal cost of new laws is low because all the important laws already exist.
sbinthree··on US Congress passes Covid-19 bill that would make illegal streaming a felony
Like sneaking in more changes after your code review is approved.
sbinthree··on ‘Friend’ influencers drive more sales than ‘opinion-leaders’
That kid from your high school with a t-shirt hustle has now experienced globalization so we have 40 kids all very good at hustling t-shirts dominating the entire t-shirt hustle.
sbinthree··on Let the ultra-rich and influential skip the line for Covid-19 vaccines?
Set a price high enough that this becomes clearly a good thing: what about $25k/person, spent directly on vaccines for others? I've been thinking about the whole "public vaccination" virtue signaling that politicians have been doing. The most ethical path would be to be immunized publicly as a politician at the same time as your risk group rather than before, ideally as the last person in your risk group so you have skin in the game. Whoever is overseeing the vaccine program should go last, for skin in the game.
sbinthree··on Depression in Childhood Tied to Physical Illnesses in Young Adulthood
I was depressed my entire childhood until I was diagnosed with Celiac at 20 and changed my diet. Then I realized it was just immune system recursively attacking nervous system.
sbinthree··on Ask HN: Co-founder wants me to leave but won't entertain a buy out offer
Agreed with this. Retain your own counsel and do this.
sbinthree··on Stanford apologizes after doctors protest vaccine plan that put frontline last
I remember being in a Canadian ICU with a family member and thinking it was weird that no one wore masks. What if someone in there had the flu? They made you wash your hands but masks were only for sick people (lol).

Seeing people with an IFR of 0.07% demanding vaccines destined for people with IFRs of 10% is a little surreal. Apparently you can learn statistics or medicine, not both.

sbinthree··on Some Vials of Covid-19 Vaccine Contain Extra Doses, Expanding Supply, FDA Says
It reduces logistical volume of the shipped product I think was the rationale. Not sure about the other questions.
sbinthree··on Tensions in Google's ethical AI group increase as it sends demands to CEO
This is the kind of thing the General Counsel gets out of bed for. Civil war.
sbinthree··on Silicon Valley exodus: Bay Area tech companies leaving for Texas
I agree, I'm arguing that the thing that leads to network success tends to also be the reason it unwinds. Facebook would not have worked if privacy prevailed, which is also the main driver impacting the unwinding of their network.
sbinthree··on Silicon Valley exodus: Bay Area tech companies leaving for Texas
I think it's interesting that people forget anything network based tends to unwind just as fast as it winds up. Decorrelation (e.g. low viral coefficient) can be antifragile. If everyone moves to your city for a different reason, it is more resilient to downturns than if everyone moves to your city for the same reason and conditions change. Facebook may unwind for the same reason it was successful: the lack of privacy.
sbinthree··on Adding Encrypted Group Calls to Signal
It provides a user the ability to see unencrypted message details on an unlocked phone. Similar to, you know, looking in the app and taking screenshots.
sbinthree··on Ask HN: Re-infection data for SARS-CoV2 / vaccine viability
The half life of the antibodies averages six months but varies. It's not as severe at diseases like smallpox where a single exposure results in antibody production for life. So our body will make energy trade offs by ramping down antibody production, including to zero. Antibodies aren't the only immune response, you can also "train" your T cells. It's the difference between having a team of soldiers train for a particular enemy, vs. training for "enemies at large". It is likely that the first exposure would lead to the most serious infection, because of the delay in the short term immune response due to novelty. This is why people have a really bad week two with covid (delay followed by panic). It could end up being like the flu, where due to mutation and waning immune response getting the vaccine annually makes sense. It's unlikely we would need the vaccine every 6 months for healthy people.
sbinthree··on Three Business Lessons Every Leader Should Take Away from 2020
Summary: be antifragile.
sbinthree··on Almost one in five Americans may have been infected with Covid-19
We are way better at treating it, there's just so many more cases. A lot of invisible cases where people get hardcore antivirals a day before they would be hospitalized, etc.
sbinthree··on Nasal Spray Prevents Covid Infection in Ferrets, Study Finds
Awesome news, for Ferrets.

Just kidding, this does seem like a very handy therapuetic.

sbinthree··on Intermittent fasting from dawn to sunset induces anticancer response
In practice it almost certainly means OMAD after dark.
sbinthree··on Joe Biden's private equity plan
He does seem to have some good eastern deal flow.
sbinthree··on ‘False Dawn’ Recovery Haunts Virus Survivors Who Fall Sick Again
My wife, son and I have had a weird experience like this. We were not test confirmed, but we are younger, so none of us had it that bad. We had a flu-like illness of coughing, tired, high fever. Then it subsided. Then a week or so later, I woke up in the middle of the night with shortness of breath. Felt like I had to mechanically breathe. Very unpleasant. Spent about two days or so like that, then was quite tired but could breathe a bit better. Then every week or so we will have another wave where we are pale, tired, headache and mild(er) shortness of breath. It feels like just recently we have come out of it, and we first had symptoms the second week of March.
sbinthree··on Serological coronavirus testing could be key to economic reopening
The reagents are contract manufactured in China by four companies who are not allowed to ship them outside of China. Going to be an interesting next couple of months.
sbinthree··on Companies fret as costs soar for software subscriptions (2019)
I think something that isn't discussed much are the runaway effects of being a winning platform. Even something uncorrelated (as opposed to network effects driven) like Stripe eventually has the ability to outexecute companies of any size and charge monopoly profits.
sbinthree··on The College Wealth Premium Has Collapsed
N=1 anecdata, I'm 26, net worth of ~$10M, barely finished high school. Avoided University on purpose because spending 4 years not working in tech seemed really expensive opportunity cost wise. Was the right choice. Can't be a doctor without going to college, but you can get rich.
sbinthree··on MIT Students Think President Reif Should Also Resign over Taking Epstein's Money
The Calabrian mafia is tumbling somewhere around $100B worth of money around the world financial system, probably indirectly funding many idealistic SV companies, and this guy has to lose his job running MIT because they accepted a donation from Epstein? Crazy. Maximum scape goat, minimum agency. Being famous is the definition of double edged sword.
sbinthree··on James Watson, “father of DNA” still believes in link between race, intelligence
The science is not uncertain. And these views are still mainstream, perhaps more so.
sbinthree··on Stocks prices are a proxy for our beliefs about the future
The world made much more sense when I realized money is just a proxy for "want". One will never have enough, so long as one "wants", which in my experience is basically what everyone does all the time.
sbinthree··on Older brains' increased knowledge slows recall speed
Synaptic pruning is the evolutionary equivalent of the postgres vacuum command.
sbinthree··on Ask HN: Have I lost my skills in programming?
Programming is weird. The better I get through experience and painful failure, the more I have tool anxiety. It starts with using a package for everything, now I fear updating my database drivers which tend to be the only code outside the standard lib I use. I have way more fear about exceptions and robustness. Every time I learn something hard ish like recursion I get worse for a while trying to use it all over the place. Then you learn the flaws. Now I feel like I spend all my time data modeling and liberally profiling and logging stuff, the code slinging itself barely takes time at all so I forget how much I've learned.
sbinthree··on Ask HN: Founder selling some shares
The bottleneck to making more money isn't directly employees, it's leadership. Market wins.
sbinthree··on Ask HN: Founder selling some shares
This is standard now, so that the founder can buy a Tesla and a house and get focused on the long term to maximize the company without taking the first buyout. Employees job is to do the work, trust them to understand. Don't buy a Ferrari and you'll be fine.
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