siver_john

Strictly speaking you can, and not knowing the exact reasons this approach is moved to human trials where others have not, I can only conjecture.

However, the mRNA vaccine may be more stable in a way that makes it easier to make or store or for entrance into the body. Not to mention purification steps may be easier. You don't need to make this in some exotic cell line which creates a protein soup you have to purify. It may be easier on the body (less likely to develop a severe immune reaction), or it may be better at generating a sufficient immune reaction because a lot of mRNA development has gone into finding molecules that are readily taken up by the immune system regardless of cargo.

These are a few reasons I can think I am sure I am missing some and there may be a stated answer out there that I have yet to search for.

To be fair when I push the meme I do it because I personally dislike Pineapple, I sincerely don't care what people put on their personal pizza, just don't put it on mine. Counter, I have enjoyed Brussel Sprouts on pizza and I feel that is a much bigger sin.

With respect to why the developer of this particular developer went the way he did, he specifically wanted to give people the feeling of working with a modular synth. So while strictly speaking it may be "better" that was not the goal. The developer in particular has always been fascinated with the tactile experience.

1) The original linked article is not a link to a scientific work. Therefore it's credence should be taken with a grain of salt as news articles need clicks more than they need boring sounding article titles.

2) In science often abstracts or intros open with grand ideas before settling into a much smaller scope.

3) The rise of predatory journals, not to mention people citing pre-print arXivs means even if something looks likes a reasonable article, it's good to get the opinions of other experts.

4) Just because something works doesn't imply how practical it is for actual deployment. (I've been to plenty of chemical talks about fantastic polymers, I've only ever seen one turn into anything of value.)

I'm responding to this because I think this comment misses the point of the exercise. Why give so great emphasis in translating this work? Because it is current. The subtlety of Japanese culture and importance in the language can often be hidden in the more modern culture. Should the works of Locke be looked to to understand the intricacies of the modern British dialect? Or should something like The Crown be a better work for foreigners to study?

The writer is specifically showing subtleties in the language used today which has nuance beyond a direct translation and why it works. I think that is highly important and commendable. And if we are to speak to something which would immortalize someone in history I believe if someone would write a companion guide to the brilliance of word play in the Monogatari series, that it would put them among the most famous translators of other foreign works. (Or even more impressively just managed to translate the word play directly.)

As the patron saint of my state, I'd also point out that she has used the money from her music to invest in other things. She is quite a shrewd business woman and I think even with 10 years she would have been fine.

Though I think 20 years is reasonable enough.

This kind of reminds me of a short project from a guy I knew in college:

https://github.com/AndrewBelt/WiTeX

It reminded me of my days in college where professors encouraged us to use Matlab. A variety of reasons made me not like it but one of them for sure was the realization that the moment I left college Matlab would no longer be "free" to me.

Yes, I know Octave exists, no it can't do everything Matlab can do and a lot of the programs I saw used needed Matlab specific things.

I think you may be thinking of the physics Nobel Prize which is work related to climate change, the chemistry has no direct relation.

I think the importance of organocatalysts besides being potentially less "harsh" is that they can also be more selective in what reactions they allow, which would be important in getting to those polymers. For example most of the amino acids in biology are L-enantiomers. So the reaction in the primordial soup would require catalysts which would bias towards that specific shape, where as a metalocatalyst may be less specific and generate both the L and R enantiomers at equal or near equal rate. Also it could also be that metalocatalysts generate side products at a higher rate such that it consumes say some of your amino acids unhelpfully. So you may be able to think about it as an intermediate step of metals->organocatalysts->polymer catalysts.

Full Disclosure: Am not a chemist but work with chemists, one of which follows MacMillan closely. And have sat through a lot of presentations looking at how different catalysts affect selectivity of products.

As someone who sits on the bounds of a lot of fields, I have to say it is surprising what many scientists think are "common knowledge." So having never seen your presentation I would question whether it is even a scientific literate layperson would actually be able to follow.

I distinctly remember being in a room of biologists and having to explain that, your general STEM audience does not automatically know what a protein is. They were incredulous, but I pointed out that I had to just explain that to a computer scientist like a week prior.

For example to you as a physicist I'm sure I could casually drop the word "force field" and you would know exactly what I'm discussing but a biologist or even chemist wouldn't. But it's such a casually thrown around word in my specialty we will just use it without thinking. Similarly Newtonian physics/classical physics/etc.

I believe the point is more from a relatively "simple" molecule you can have catalytic reactions that don't require metal or complex protein systems. When applied to the observation about life means that random organic compounds could have started selective catalytic reactions which could have given rise to more complex systems which then give rise to the building blocks of life or something.

This is me speculating on the meaning of the original comment, my knowledge of abiogenesis is lacking and I know RNA can do some enzymatic reactions which are also organic compounds.

Never had seen Hugin before, I was wondering how people did that open source recently.

And with respect to color management and Wayland with the rumored next release of nvidia drivers potentially supporting Wayland that's about the only thing that would stop me from switching on all my machines. I know there is an open issue for working on that in both the Wayland official protocols and wl-roots so hopefully soon.

I know for Tensorflow, ROCm keeps their own docker image you can pull against.

Though iirc ROCm isn't supported on recent consume level cards which I find incredulous that wasn't a goal to have working from launch.

A lot of it from what I can tell is American exceptionalism. That we are special and unique and therefore what goes on in the rest of the world simply does not matter.

Often this is rephrased as the U.S. is too big or too diverse compared to European countries. Or it can be a simple ignoring of any alternatives or an active movement against. I remember hearing an NPR article about how a US construction worker wanted to go and study the methods of infrastructure improvements in Europe which tended to be cheaper in the same realm, but was denied. The reason for denial was something along the lines as it wasn't pertinent, we didn't need to know that.

As someone who tried e-readers back around the original Kindle launched, I ended up just giving it to my grandmother because it wasn't as satisfying to read as an actual book.

Recently however I gave them another shot (specifically the Onyx Boox Nova) because I started trying to refresh my Japanese and reading manga was easier than other forms of media (lots of pictures rarely wall of texts). The problem is buying manga from Japan and shipping it across the world was a pain and after reading on my tiny phone and that really straining my eyes, I decided to invest in an e-ink tablet. (Partially to use kaku on it but that did not work, however the ability to switch to a dictionary is nice).

I also used kobo similar to the author for my app because apparently their DRM was the easiest to break out of everyone which means if they go down at least I still keep my e-books.

Pentel is probably one of the most common mechanical pencil companies in the US and is Japanese. They are so common in fact I didn't even know this till I was in a Japanese language class in college and my professor asked me where my pencil was made to point out this fact and it came as a surprise.

So the Baker Lab out of Seattle has actually been working on that exact problem for a while now. There suit of programs for doing this type of work is called Rosetta and I know they have generated at least one protein from scratch.

As someone who's background is biology and physics and who does ML work as well. This is an incredibly optimistic view of ML.

>Of course, it really only works if the scientists are able to understand data and how to use ML, which is why computing becomes just a tool for a scientist, nothing else.

Ideally in science you would like to use literally anything else other than ML if possible, fitting models come with their own challenges and neural networks are even more of a nightmare. Understanding the world well enough to hard code a rule is always preferable to fitting to some data and hoping the model will come up with a rule. While there has been some attempts to use ML for feature detection it then takes a lot of experimenting to generally show if it detected signal or just some noise in your data.

Most of the things that would accelerate science would either require AI much more complex than we currently have (basically replacing lab assistants with AI) or are incredible research undertakings in their own right like Alpha Fold, Deep Potential Neural Networks, etc.

While nanoparticles could correspond to viral like carriers. The reason you probably wouldn't want to naively use viral particles is because any viral particle that would likely attack the body naturally would also trigger the immune system. That would decrease the efficacy and could actually increase the likelihood of side effects.

I have fulfilled my responsibility (in the parent) just in case this is easier to see.

If you're still curious, the podcast is Trash Taste which is a bunch of friends talking about their lives really but they had an animator on their for an episode[0], the entirety of the podcast is 2 hours long and the mention of blender is fairly short. I was trying to find a clip because they do that of their own shows, however I found a tweet [1] in looking by the guest. It may still be an interesting one to watch and two of the members Joey (theanimeman) and Garnt (Gigguk) have done tours of anime studios (CloverWorks and JC Staff respectively).

Edit: If Twitter wouldn't have wigged out on me I would have found the link to the clip I was searching for, it was mentioned in the first tweet in that thread [3].

[0] https://www.youtube.com/watch?v=z9ulkFRXkvQ

[1] https://mobile.twitter.com/kenarto/status/136386214032346726...

[3]https://t.co/4fq6LRvHmr?amp=1

I think I saw in a podcast with someone from the anime industry that it is being used for digital animation by some people there. So I definitely believe it is making inroads. NVIDIA has also included it into omniverse as a first class citizen with other more "enterprise" applications. So I would definitely say it has traction.

I do not believe a vast majority of those people are using Linux however, or at least I haven't seen any indication of it. (But maybe some companies render servers do and maybe Blender is useful for that, but like Maya works on Linux iirc)

From reading the press release. It appears as if Canonical will just handle support contracts with external companies. Basically they will have a help desk or something if those companies/their employees are having issues with Blender. Part of the proceeds from those contracts will then be passed to Blender for it's further development and to fix bugs that may arise in LTS releases of Blender. I do not believe they are hiring developers it looks more like Blender is out sourcing technical support to Canonical with a bit of a kick back.

Seems like a good partnership to me imho, granted I've never worked with Canonical's support.

I would have probably put my Zojirushi but I got it seven years ago (and am in awe at that fact now that I've typed it). And it's worked more or less flawlessly that whole time, it failing only due to user error. Just if you lose the rice cup and are an American remember that it is ~3/4 cup of uncooked rice is equal to the rice cup.

I've bought loads more Zojirushi things in the meantime and have loved every one, but none except the water boiler (a recent addition) get near the same amount of use as the rice cooker.

In the last year: Sennheiser 660s and a Schiit Stack (I wear headphones almost constantly while working and this was more than worth it).

iMovr sit stand desk, at the start of the pandemic I was using the desk built into my apartment wall that was probably fine for the occasional use at the family computer when this house was built in the 90s but was causing me a lot of pain using day to day.

Over Two Years, stupidest thing that has probably brought me the most happiness is a yutanpo I bought off of Amazon (also called hot water bottle?). There is something so satisfying about jumping into a nice pre-warmed and cozy bed at the end of a cold winter's day. (Though technically it was a gift so I don't know if it counts).

I had a similar experience but went with the Flair (cost and compactness being major factors), been a lot of fun getting into coffee generally over the last year and was something my mother and I bonded over when I had a long visit. I was not previously a coffee person before this, mostly preferring tea but trying to nail that perfect shot of espresso can be the most rewarding and frustrating thing on the planet.

I mean I get that, but they could have just said we're no longer developing this, because we're tired or whatever. I just think it's interesting they made such a strong stand.

I find this kind of interaction interesting having used both termite and alacritty. Honestly I would have never expected maintainers of what I perceived as a fairly popular terminal to just go, welp use the other guys. This is kind of neat.

I had already been using alacritty for a while because it had wayland support, even though it has some weird bugs on my current i3 setup where creating a new terminal just creates an unresponsive window that has to be killed through htop. Other than that it's been great, and there is something satisfying about cat /udev/random and the text that flies by with GPU acceleration.

Nah, nano is probably fine for what you are doing. It excels at quick short edits.