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snitty

954 karma · joined April 20, 2023

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snitty··on Aromatic 5-silicon rings synthesized at last
In this case aromatic means a ring of atoms where there is electron sharing among all the members of the ring.

They're called aromatic rings because before they understood the structure, they grouped them by their behavior, and the aromatics contain a lot of volatile organics like benzene, toluene, phenol, which have strong odors.

snitty··on Aromatic 5-silicon rings synthesized at last
>Move over cyclopentadiene anion—there’s a new five-membered aromatic ring in town, and this one is made of silicon.

CHEM-Es are build a little different from the rest of us.

snitty··on GPT-5 outperforms federal judges in legal reasoning experiment
So here the test was effectively given a set of relevant facts, can we influence the way a judge (or LLM) rules based on superfluous facts. The judges were either confused or swayed by the superfluous facts. The LLM was not. The matter was one where the outcome should have been determinative, not judgment-based, under US law.
snitty··on GPT-5 outperforms federal judges in legal reasoning experiment
Arguing that this is a Common Law matter in this scenario is funny in a wonky lawyerly kind of way.

The legal issue they were testing in this experiment is choice of law and procedure question, which is governed by a line of cases starting with Erie Railroad in which Justice Brandies famously said, "There is no federal common law."

snitty··on Show HN: Shelvy Books
I miss Delicious Monster's Library app
snitty··on Cadova: Swift DSL for parametric 3D modeling
I find this much more readable than KCL[0], but I also understand the ultimate goals of the two are probably a bit different.

[0]: https://zoo.dev/docs/kcl-samples/pillow-block-bearing

snitty··on Cloudflare Global Network experiencing issues
That's why I run my server on 7100 chips made for me by Sam Zeloof in his garage on a software stack hand coded by me, on copper I ran personally to everyone's house.
snitty··on A laser pointer at 2B FPS [video]
But that bears no relation to what happened in the video.
snitty··on A laser pointer at 2B FPS [video]
>As I understand it, this is sort of simulating what it would be like to capture this, by recreating the laser pulse and capturing different phases of it each time, then assembling them; so what is represented in the final composite is not a single pulse of the laser beam.

It is not different phases, but it is a composite! On his second channel he describes the process[0]. Basically, it's a photomultiplier tube (PMT) attached to a precise motion control rig and a 2B sample/second oscilloscope. So he ends up capturing the actual signal from the PMT over that timespan at a resolution of 2B samples/s, and then repeating the experiment for the next pixel over. Then after some DSP and mosaicing, you get the video.

>It seems like if you could measure the pulse's propagation in one direction, and the other (as measured by when it scatters of the smoke at various positions in both directions), this seems like it would get around it?

The point here isn't to measure the speed of light, and my general response when someone asks "can I get around physics with this trick" by answer is no. But I'd be lying if I said I totally understood your question.

[0] https://www.youtube.com/watch?v=-KOFbvW2A-o

snitty··on Forth: The programming language that writes itself
I remember programming in Forth on my Palm Pilot, as there was a Forth interpreter for it.
snitty··on Nobel Peace Prize 2025: María Corina Machado
Is the US going to invade Oslo in retribution?
snitty··on Gifted children are special needs children
How many years were you in kindergarten?
snitty··on Qualcomm to acquire Arduino
And yet there is clearly a market for easy-to-program MCUs for hobby and educational purposes.
snitty··on Clavier: An FPGA-based mechanical keyboard with USB hub and comms interfaces
I'll remember that next time I'm developing an FPGA keyboard for my Gateway computer.
snitty··on Clavier: An FPGA-based mechanical keyboard with USB hub and comms interfaces
The FPGA is a Lattice LFE5U-25F, about $20

https://www.digikey.com/en/products/detail/lattice-semicondu...

snitty··on ABC yanks Jimmy Kimmel’s show ‘indefinitely’ after threat from FCC chair
Two things here.

1. Trump was president in 2019 and 2020.

2. There is an important difference between a bureaucrat calling up someone at Facebook at arguing a position about policy and the chair of the FCC threatening to remove broadcast licenses. Notable, Supreme Court has even weighed in on the former and found it well within the rights of the government to do.

snitty··on ABC yanks Jimmy Kimmel’s show ‘indefinitely’ after threat from FCC chair
I, too, remember when Obama has the FCC commissioner threaten to revoke broadcast licenses for the coverage of his tan suit.

This type of both-sides-ism is dumb, especially here when one side is using the power of the federal government to get dissenting voices taken off the air.

snitty··on Stripe Launches L1 Blockchain: Tempo
US banks literally collapsed the world financial system in 2008. You don't deserve humble regulation after that. They got, and they deserved, the Dodd-Frank Act, which has now been significantly rolled back.
snitty··on Show HN: I built FlipCards – a flashcard app with variations to improve learning
Is this web only? Are there apps? Hard to sign up for something when I have no idea what I'm buying.
snitty··on Manim: Animation engine for explanatory math videos
https://www.youtube.com/watch?v=rbu7Zu5X1zI&t=19s&pp=ygUFbWF...
snitty··on Blood oxygen monitoring returning to Apple Watch in the US
>monopoly on blood oxygen measurement in a wearable electronic device

And I know this isn't your argument, but that's a VERY narrow market for the purposes of a US inquiry into monopolies. Like, the normal market definition fights are about whether you should be considering "premium smartphones" or "smartphones" as a whole. Or all of the grocery stores in a given region, and whether that should include convenience stores that also sell groceries.

I'd be hard pressed to imagine a court really contemplating an argument that a company has a monopoly in a very small slice of a market. It would be like saying that Rolex has a monopoly in luxury sport watches with headquarters in Geneva.

snitty··on Third patient dies from acute liver failure caused by a Sarepta gene therapy
This gene therapy involves a gene called dystrophin, which is one of if not the largest gene in the human genome. Sarepta is actually using a version called microdystrophin, which is a truncated version. It still barely fits into AAV.

Reasons to use AAV: they're going for sustained production of the therapeutic gene, and AAVs are better at doing that than LNPs. LNPs were used in the mRNA COVID vaccine, because they're great at transient production.

To get stable production from an LNP you'd likely have to integrate into the genome, which risks cancer from disrupting oncogenes. You'd also need to package the therapeutic gene with a mechanism of integrating into the genome, like recombinase.

snitty··on Third patient dies from acute liver failure caused by a Sarepta gene therapy
I've been working on a piece about how humans effectively have hardened firmware, and gene therapies need to do A LOT to try to get around the various defenses our bodies evolved. I should probably finish that article...
snitty··on Apple vs the Law
I honestly didn't expect the "it's just one line of code" argument on Hacker News.
snitty··on Nvidia won, we all lost
NVIDIA is, and will be for at least the next year or two, supply constrained. They only have so much capacity at TSMC for all the chips, and the lion's share of that is going to be going enterprise chips, which sell for an order of magnitude more than the consumer chips.

It's hard to get too offended by them shirking the consumer marker right now when they're printing money with their enterprise business.

snitty··on Fixing the mechanics of my bullet chess
I only use chess tools that allow for vim bindings. /s
snitty··on Endometriosis is an interesting disease
>Yep this is something that only AI can solve.

[citation needed]

snitty··on Student discovers fungus predicted by Albert Hoffman
>Question - how is it significant, considering they sent it off to another company to do the sequencing?

It's actually a little more complicated than they made it sound. What the student likely did was assemble the genome.

When you send DNA out for sequencing, you get back files of 100-300 basepairs. You then need to do assemble them into a genome by figuring out where all the pieces overlap.

Obviously there are tools that help with this, but there are lots of fiddly bits and settings that you need to play around with to get it right.

snitty··on Devstral
I think your options are generally:

0) A desktop PC with one or more graphics cards, or 1) A Mac with Apple Silicon

snitty··on They Paid $3,500 for Apple's Vision Pro. A Year Later, It Still Hurts
I demoed the Apple Vision Pro. It demos incredibly well. And there's very little to do with it.

This isn't a problem unique to the Apple Vision Pro. There's still relatively little to do with an Oculus, PSVR2, and many other headsets.

Honestly, my favorite part about my PSVR2 is the ability to cut off most everything other than what I'm doing just then.But it's kind of a lot of work for that feature.

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