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squozzer

418 karma · joined August 31, 2011

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squozzer··on Engineering Brain Parasites for Intracellular Delivery of Therapeutic Proteins
Here's a similar technique used for leukemia -- https://usingaidstofightleukemia.weebly.com/
squozzer··on ‘I’m Broke and Mostly Friendless, and I’ve Wasted My Whole Life’
Expectations. I think Haunted believed it would be easy to have it all.

>But your concept of yourself makes no sense. You got it from a rom-com.

Bingo. Everything is a trade-off. On top of that, our best-laid schemes often go wrong. Sometimes years or decades of sacrifice to a career, relationship, or family makes one worse off, not better.

I don't know if a perfect system exists for living one's life but here's a nugget or two -

1) Love is a choice, not an emotional state (learned by watching my Dad.) 2) Reassess often. 3) Don't fear changing things, including yourself. 4) Most people will die having achieved little that others would consider worthy of praise. That includes the others. 5) Having lived at all is something 99.99999999+% (by mass) of the Universe will never experience. Though maybe I'm wrong here - stars, nebulae, and galaxies may actually be alive for all we know.

squozzer··on 'Talent Wants Transit': Companies Near Transportation Gaining the Upper Hand
For me, transit not so important but a low-hassle commute is. If transit is the only way to achieve that, great.

For example - When I first worked at my current job, it was a 45-90 min drive over interstate. A year later, I moved closer and now it's a 15-30 min drive over regular streets.

Upsides: Lower commuting stress - even when my current drive home looks fubar, I can tolerate it long enough to either get home or find a pub and wait it out over a brew.

Downsides: My housing costs tripled.

My previous job was a 30-60 min drive, but later took a shuttle bus that had a stop right in front of my job.

Upsides: After 30+ years of interstate commuting, taking my hand off the wheel for a couple of years was a godsend.

Downsides: The bus stop was basically a street corner with no shade or rain protection, so waiting for the bus on some afternoons was a bit challenging.

squozzer··on 30,000 empty homes and nowhere to live: inside Dublin’s housing crisis
It seems cities with housing problems where AirBnB is a factor could adopt a property tax scheme similar to what US counties implement already -

1) Tax based on property value (ad valorem); 2) Ad valorem deduction if owner lives on property (homestead exemption)

PLUS some tax distinction for "declared" - not sure if verifiable - long-term (6 - 12 month minimum) vs short-term (AirBnB) rental.

I think taxes might work better or at least sound less draconian than simply banning AirBnB or restrictions such as when rooms can be let (e.g. Jacksonville Beach FL had some kind of ordinance restricting lets to certain months of the year.)

squozzer··on Japan Is Giving Away 8M Abandoned Houses
In Detroit some people - actually, Bill Pulte - are razing dwellings with an eye on redevelopment.

https://www.theblightauthority.com/

squozzer··on Star Power: Carl Sagan’s 1970 Porsche 914 (2016)
I would argue "no" on Sagan's effect on the car's provenance.

Not an expert, but years of watching Barrett-Jackson and Mecum auctions (along with their commentary) leads me to conclude the following will generate interest:

1) Cars owned by famous racers

2) Cars owned by other famous people who like to race, e.g. Paul Newman

3) Cars involved in a well-known incident, e.g. Bonnie and Clyde http://www.weirdca.com/location.php?location=283

4) Cars owned by celebs who have expertise and resources to maintain their cars well, e.g. Leno and Seinfeld

The car itself must be exciting - Jeff Gordon's minivan won't cut it.

For instance, I think people are still looking for James Dean's Porsche.

One of Howard Hughes' cars did OK - https://www.hemmings.com/blog/2014/12/19/howard-hughes-recor...

OJ's Bronco? Maybe not so well.

squozzer··on NYC subway and bus services have entered 'death spiral', experts say
The problem seems fixable, but as others have said, people will have to take some lumps.

A certain political figure with strong (both bad and good) ties to NYC has harped for a couple of years about a federal infrastructure bill. I think the phrase "third world" was used to describe the problem.

No reason why America's Greatest City (tm) could not wring a couple of bil out of the feds to start upgrading their subways. Move back to the first world, you might say.

In turn, because we're talking about a transaction, the MTA might also need to move out of a "third world" mentality. We can safely assume some of their payroll is spent on political favors. Maybe this "death spiral" talk will motivate the agency to make a least a token gesture towards good use of their riders dollars.

Maybe.

squozzer··on Italy’s olive crisis intensifies as deadly tree disease spreads
I think we could apply the terms "nationalist", "patriotic", or even "chauvinistic" terms in this context without too much penalty.
squozzer··on A French Novelist Imagined Sexual Dystopia. Now It’s Arrived
I think some of what hampers young guys love lives is the assumption that only "perfect" - in situations as well as looks - girls are worth dating.

Generally, "peer" women - that is, women of the same age and social standing - are "sleeping up." Because they can.

That said, plenty of niches exist for the enterprising -

1) Single moms 2) Older women 3) Girls you knew in HS / college

squozzer··on Marriage 101: There Are No Soul Mates
I remember someone publishing a book called You Need A Cellmate Not A Soulmate. Maybe I'll buy it.
squozzer··on How Harley-Davidson's All-In Bet on Its Past Crippled Its Future
Not a rider, but HD's story sounds very similar to Gibson's and Fender's - whose past is going extinct but having difficulty moving or even figuring out their future.
squozzer··on Russian Hackers Largely Skipped the Midterms, and No One Really Knows Why
>as an influencing factor in US elections

Allow me to add "significantly" as a modifier to "influencing factor".

In 2016 we were primed to look for signs of Russian interference once Hillary accused Trump of collusion.

In 2018 we were warned of non-specific Russian (and Chinese) threats, but had no direction on where to look, so we didn't see much of anything.

The contrast was enough to make us believe the Russians were a no-show.

squozzer··on Russian Hackers Largely Skipped the Midterms, and No One Really Knows Why
Here are a couple of hypotheses -

1) Russian hackers, as an influencing factor in US elections, never existed; 2) Russian hackers grew disillusioned with Trump when he failed to go full Quisling and surrender the USA to Putin.

squozzer··on One day I'll give all the project managers a GCSE maths paper to complete
Don't forget to fire anyone who can actually complete the tasks given; they'll be the ones your boss will hire to replace you.
squozzer··on California moves toward permanent daylight saving time
I think you mean MST.
squozzer··on Grievance Studies Goes After the Scientific Method
Maybe we should treat GS as a religion instead of a science.
squozzer··on Twilight of the Racist Uncles: How Facebook is melting the minds of our elders
My experience was similar but in the opposite political direction. One of my FB friends in particular went from harmless "neo-hippy" (e.g. crystals, sacred shakras) to Leon Trotsky, essentially passing along every anti-DT statement that would pass a spell checker.

And the recent SCOTUS confirmation essentially shot them into a mental orbit reserved for people such as David Koresh. Escape velocity from reality? Achieved.

squozzer··on Kessler Syndrome
I guess we better get some people off this rock before earth orbit becomes unnavigable.
squozzer··on He won Powerball’s $314M jackpot. It ruined his life
About 30 years ago, I read a book about lottery winners and the stories read very similar to Mr. Whitaker's, back when a mere million dollar payout was a big deal.

Though it's possible the book had a selection bias - because who would read the stories that ended happily ever after?

I'm not sure regular schmoes can avoid problems with large sums of money because we're not used to dealing with wealth or the problems it attracts. Rock stars, pro athletes, and even heirs to family fortunes have similar problems.

Given the likelihood of winning, I've already spent too much time thinking about what life modifications might be needed but here goes --

1) If you know or can access someone who has tons of money (e.g. Bill Gates), ask them. Though people such as Bill Gates probably have most of their wealth in investments, not cash.

2) Get a second address or at least access to a place under someone else's name. Assume your driver's license info will become public knowledge.

3) A couple of lawyers on retainer is good, at least one who specializes in defending against frivolous lawsuits. Maybe one who specializes in such lawsuits, just to knock them out of the pool of possible attorneys who would come after you. I heard Michael Avenatti might be available.

4) Having a friend or two in the police might help, they can find people willing to pull security details. The key phrases here are POST-certified, sworn officers. I'm not as big on hiring military-grade "operators" but maybe if you find yourself dealing with kidnappers or other hard-core types...

5) I prefer lump sum, because governments have a reputation for altering plans. Not to say a government wouldn't just confiscate one's holdings, but it's usually easier to not give something than to take it back.

6) If you are a man, seriously consider a vasectomy. That won't stop the paternity suits but you'll sleep a bit easier. Apparently celebs have doppelgangers who bed women on the reputation of others. That may be a harder scam to pull off in the age of smartphones.

squozzer··on Stripe hires Niels Provos away from Google to be its new head of security
Did he sign an non-compete?
squozzer··on A Nobel Prize-winning physicist sold his medal for $765,000 to pay medical bills
We should consider the possibility that Dr. Lederman's financial problems happened by design.

After all, why should ordinary people be allowed to slowly amass modest fortunes to pass onto their heirs?

If you want to know who is truly elite in America, see whose debts cannot be discharged through bankruptcy.

squozzer··on Ask HN: Was hired to improve company's devops, founder won't listen to my ideas
You are probably a scapegoat. Pull the ripcord.
squozzer··on McMansion envy spreads as Americans demand more bedrooms and baths
>People with more money to spend typically want five bedrooms with bathrooms, porcelain tile and quartz countertops. “Most everything we’re doing at this price point includes a garage that fits a minimum of four cars,” Jackson says. “We just finished a home that had a nine-car garage.”

I just contracted McMansion Garage Envy. Maybe with a dash of prepper amenities such as an RTG https://en.wikipedia.org/wiki/Radioisotope_thermoelectric_ge...

and a protected well.

squozzer··on McMansion envy spreads as Americans demand more bedrooms and baths
Enjoy McMansion Hell - http://mcmansionhell.com/

I call BS on the single-story build rate > 40%. Finding my current home in 2015 - a single-story - took a lot longer because they weren't that many on the market at a given time. Some were under contract in less than one day on the market! But I am confusing build rate with market availability.

The blame will fall on HGTV for some of the problem.

Another factor is profitability - a 2000 sqft house costs less than 2x to build than a 1000 sqft house, but within the same hypothetical neighborhood, will probably cost 2x or more because of the additional features that additional floor space makes possible.

squozzer··on Secret Hospital Deals That Squelch Competition
It's worthwhile to check our assumptions - in this case, that insurers dictate all terms. Maybe it's correct.

But we lack the visibility to know if it's true about every component in the system.

That said, I share your sentiment. He who has the gold (usually) makes the rules.

squozzer··on No, I will not debate you
Here's an example of why it's useless to debate Ms. Penny --

> If Bannon has to have a public platform, make him work for it.

Fine.

> Have him stand on a stage and play the audio footage of the toddlers at the Mexican border screaming for their parents as they’re dragged away to detention.

Without examining actual data, how does she or anyone know the adults accompanying the toddlers were their parents? Or is that an assumption used for maximum emotional effect?

> Have him answer to the mothers of children who were gunned down by police because of the color of their skin

An assumption that we can read the minds of police officers.

> or to the friends and family of migrants who drowned in the Mediterranean.

Whose safety and happiness apparently rests solely on the shoulders of Europeans.

>That’s not a polite thing to say. It wouldn’t be a polite thing to do. But the idea that politeness and civility is owed to anyone in a position of power is one of the great gotchas of liberal thought.

No, it's not Ms. Penny. Moreover, it's as intellectually dishonest as anything Steve Bannon says. Because implicit in the statements is somehow we have to take extraordinary measures for children we've never met. To assert otherwise is to be labeled infanticidal. Not that Ms. Penny would ever use such a term. But that's the effect her statements intend to achieve.

squozzer··on PayPal’s crackdown on ASMR creators
Huh. And I thought ASMR made sleep vids - rain sounds on a tent was my favorite.

But considering how making unverifiable claims seems to be so effective nowadays, it doesn't surprise me much anymore.

I pity those caught in the whirlwind. Let's hope sanity returns soon.

squozzer··on Let’s bring back the Sabbath as an act against ‘total work’
You know what would be really cool? 365 / 5 = 73.

So if we eliminated Saturday and Sunday, we could work all year round. 73 weeks of fun-filled, delicious work each year!

squozzer··on Let’s bring back the Sabbath as an act against ‘total work’
It all sounds a bit legalistic. I say that with a grin.
squozzer··on The iPhone SE was the best phone Apple ever made, and now it’s dead
Damn. The SE is my fave too. BUT, I only owned a 4s prior. So my experience is rather limited. My GF has a 5c, and the SE is lighter than a 5c.

The 6 and later versions were too big, for bigger screen needs I have an iPad mini. Which also seems on a glide path to obsolescence.

If we were limited to one Apple mobile device per person by decree, then maybe the bigger iPhone would make sense.

Understanding that Apple wants to avoid hyper-customization a la IBM PS/2 AND wants to maintain an air of avant-garde, some decent products have to be sacrificed.

A poster made a comment about working with the SE's limitations when designing apps for the SE. Some apps (such as Amazon) looked very crowded on my SE. Another (Manhattan Metal Prices) looks great

Maybe the SE died because it forced unwanted simplicity on app devs.

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