Having spent a bunch of time trying to figure this all out myself, as well, some practical tips (confirmed anecdotally by yours truly):
- Place your speakers such that they form an equilateral triangle, with the tweeters pointing directly at your head while you are seated in the control position. Near-field monitors are made for focusing on a 'sweet spot' like this. Using purpose-built speaker stands is the easiest route here.
- Treat the first reflection points with foam, or anything that absorbs/scatters sound (e.g. I hung a huge shag rug on the back wall)
- Break up smooth surfaces (walls/floors/windows) with other absorptive/non-smooth decorations and materials. Rug on floor, couch at back of room, curtains, even a bookcase; all will help absorb and scatter sound.
- A good rule of thumb is to spend as much money on 'treating' the room as the speakers themselves (even great speakers will sound like trash in a room with no treatment).
- When using the speakers for mixing/mastering work, listen at a conversational volume. The lower the volume, the less the room matters (and the room matters a lot).
- You will get far better sound from decent headphones (I have HD650s) than from all but the most pristinely designed/tuned monitor setups. Probably would cost well over $10k and a lot of knowhow to beat the headphones.