I've been using them for a few clients now and it's been a fundamental shift in how we think about media management in the CMS. Rolling out new features with different image size requirements using existing media doesn't require us doing anything other than changing a few parameters in the URL. Before, we'd have to run processing tasks on a fleet of EC2 instances and wait a few days.
We compared a few similar services, but none of them really got the flow right like Imgix does. Some require you to setup the parameters beforehand or define everything in their web interface or via a REST api. And quality wise, none of them are near as good as Imgix.
I can't sing their praises high enough honestly.