As a Nexus 5 user I'm pleased with most of the changes and non-changes. 2GB is fine for a smartphone, and an image sensor with more than double the light capture area per pixel is brilliant, and if it delivers the better photographs will be worth it right there. Losing OIS...I don't think that's a downgrade as OIS was always suspect to begin with (not least because OIS only helps for lateral movements. It does nothing for rotational movements, and of course make subjects stand still. It yielded a tonne of unusable photos).
The only thing I'm really displeased about is the removal of wireless charging. That was a really nice feature.
Between the Snapdragon 810 and 808, the only real items of concern is that the 808 does not have h265 hardware encoding (the 810 does), and its image processing DSP is 12-bit per pixel rather than the 14-bpp of the 810.