There is a paved road to clinical depression which starts with thoughts like these. I know it because I've taken it.
Life stops having meaning if you take this too seriously - I mean, why do anything or achieve anything if we're just specs in time and space destined to die and be forgotten ?
Besides, this doesn't necessarily imply humility. If it doesn't matter then it doesn't matter - if you've got a small/quiet ego or you're a larger-than-universe egomaniac... because... we're just a minute...