If the tox.chat devs would just make some alpha release tarballs I would package toxcore for Guix.
Gentoo and Arch packaging pulls source from git. Can Guix packaging be done from a VCS checkout?
Yes, and I've packaged that them that way for my own personal use, but it's really annoying to deal with because I have no idea which clients work with which revisions of the toxcore git repo. Some official alpha releases would make this much more manageable.