This is quite interesting and if in 1966 Sacks was encountering this unusual case of prime numbers in his patients, then this undoubtedly led to his life-long fascination with prime numbers, I suspect. He is well-known to have enjoyed a book on prime numbers published nearly 50 years later, The Music of the Primes: Searching to Solve the Greatest Mystery in Mathematics, saying "I could not put it down once I had started." I like to think that two autistic twins inspired in Sacks a life-long enjoyment of this area of mathematics; that random encounters that can shape your thoughts for decades.