My favourite real-life example of it's usage is one in which we know that the gender is female, and we know it's singular:
"If a mother wants to use the nursing room, they can just key in the code in their pamphlet".
[1] https://www.reddit.com/r/linguistics/comments/3cgbyv/limitat... gives some good discussion
[2] I can't help but feel that these restrictions are related to nondefinite contexts for "(negative polarity items)[https://en.wikipedia.org/wiki/Polarity_item]", like 'no-one' and 'any', where you can't say e.g.
*I ate any cake
but you can say: I didn't eat any cake
but you can also use it in questions: Did you eat any cake?
This seems related to usages like If someone comes, tell them to wait
vs *If John comes, tell them to wait.It sounds a bit more natural if you say "That user didn't read the article, so they were uninformed."
It does when the gender identity of the subject is known to be neither he nor she!
I'm not a fan. If we have to go somewhere, I'd rather go with 'it'.