I'm just not sure what the advantage is. I don't take alcohol, other than the occasional beer/wine, as I don't particularly like the effects. Same for smoking/caffeine/pot. I have much better experiences with real-life, such as flying planes, climbing mountains, etc. I understand LSD and ketamine are going to give a kind of the experience you can't get in real-life, but screwing around with your brain to achieve it doesn't really seem to be worth the risk IMO. I've managed to completely screw up my brain once in my life (severe suidical depression / CFS) without any help from any mind-altering substances, so to be honest I'm not really sure it's a good idea to be screwing around with your neurotransmitters like that. It's like trying to make your zx81 do something cool by randomly poking memory locations or wobbling the 16k RAM pack.

I mean if you already have a psychotic disorder, is it a good idea to experience the k-hole (high dose of ketamine)? With or without antipsychotics? What about a low dose?

For example, would you recommend that someone with schizophrenia try it?