Even early choral scores, (~1200-1600) can be typeset by LilyPond using SMuFL compatible fonts in their traditional styles. (For examples, see the "Ancient Music" section of the documentation http://lilypond.org/doc/v2.18/Documentation/notation/ancient...)
Prior to that, there's not much written music, and that which is written is done so in a form so specific or esoteric that it will needs to be re-engraved into the traditional staff form for performance by modern day musicians.
There are some local variations that SMuFL doesn't really "handle" per-say, take Jianpu notation as one example. (https://en.wikipedia.org/wiki/Numbered_musical_notation) but those forms can typically be handled well by a standard text editing program.