Based on economic incentives, I would guess that the mining industry would conquer the new frontier way before any commercial space travel for humans--one way or two way. Unfortunately the mining industry today is the scummiest on earth. I honestly hope that Elon Musk and SpaceX get into space mining before say Rio Tinto, just because he deserves the billions more and would probably reinvest it for more socially good projects as well.
My vision of how it could be in [N=no_fucking_clue] decades: Completely unmanned from the beginning (just like mining on earth nearly already is), with a large-scale base on the moon. It starts with mining on the moon that is processed on the moon and shipped to the earth and the infrastructure is set up so that [M] decades later it would be the hub for inerplanetary mining operations as well.
Get building Mr. Musk!