Simple use case: you've got several startup projects with different domains, and multiple addresses on it. Migadu makes that painless. Family domain with emails for the whole family? Easy.
And..of course there are many alternatives. No intention to reinvent email here. Just making things more pleasurable to manage and use, by getting them out of the way.
We were also doing similar combinations for our startup projects via Google Apps and Mandrill, but it was getting very messy. I just wanted a new domain / new email address, fast. Nothing else. Somehow I would end up with multiple Google accounts, and then Google cut of the free accounts... Interestingly, Mandrill announced the same thing today. I'd rather give up two cups of coffee a month and not waste brainwaves and worries on this admin.
Migadu is meant to get email admin out of people's way so they can focus on more important stuff.