I'm not sure universities and start-ups matter that much.Israel is great at doing start-ups , probably better than the u.s.(at least at start-ups per capita). but usually the start-ups get bought by multinationals, so they get the job creation and economic power that comes with those innovations. not necessarily Israel.
While historically most big multinationals were centered around the u.s., this might be changing. The shift in multinational jobs to outside the u.s. is one datapoint. and the rise of strong non u.s. multinationals is another.just look at the Chinese green energy sector.
And take into account that change today is much faster then at 19 century Britain.