At a certain point, I think its completely reasonable to base that decision on conscience, or on what you can trivially defend to a neutral observer.

Some of Uber's regulatory battles are complex, but many are laughably transparent. France's 15-minute mandatory delay before you can be picked up by hire cars? They didn't even pretend it was about anything other than protecting a monopoly.

If a regulation has a decent purpose that you feel it's not fulfilling (especially safety), you should probably lobby against it. If the regulation's entire purpose is to manipulate a market, it becomes pretty easy to defend ignoring it.

Every single person or group of people decide which regulations to abide by every single day (download music? exceed the speed limit? hail a ride that the local taxi people don't like?).

The idea that it's not the person's job to decide which regs to abide by implies that all laws are equal. As GP mentioned, that isn't the case.