Though hosts files can be fed to uBlock Origin ("uBO"), it will enforce their content differently.

With uBO, a "facebook.com" entry in a hosts file will also cause all subdomains of "facebook.com" to also be blocked, so there is no need to list all subdomains as is done here if the goal is to block "facebook.com" with uBO.

If one wants to block Facebook via uBO, I personally advise to do it through dynamic filtering[1]. This way one can always point-and-click to create exceptions on a per-site basis.

[1] https://github.com/gorhill/uBlock/wiki/Dynamic-filtering:-to...