With vector graphics - where the lines and fills are mathematical objects - automatic 'tweening' becomes possible. Anime Studio (http://my.smithmicro.com/anime-studio-2D-animation-software....) is the zenith of this tech; there's also Synfig (http://www.synfig.org/cms/) and CACANi (https://cacani.sg/).
In Anime Studio it's possible to add all kinds of effects (including filter effects and motion blur) to animations, and to mix pure vector animation with cutout, or even frame-by-frame, animation.
Sometimes a perfect interpolation, or even something based on a physical model doesn't feel right, isn't what is expected.
I think at this moment it is not possible to instruct algorithm to take additional suggestions (artist ideas) into consideration when creating output image.