Seems like this is time to research how antibiotic resistance is jumping species. I feel like we could take advantage of unauthenticated exchange of information and inject weaknesses instead.
> Artificially constructed plasmids may be used as vectors in genetic engineering. These plasmids serve as important tools in genetics and biotechnology labs, where they are commonly used to clone and amplify (make many copies of) or express particular genes.[12] A wide variety of plasmids are commercially available for such uses. The gene to be replicated is normally inserted into a plasmid that typically contains a number of features for their use. These include a gene that confers resistance to particular antibiotics (ampicillin is most frequently used for bacterial strains), an origin of replication to allow the bacterial cells to replicate the plasmid DNA, and a suitable site for cloning.
I think that the problem would be coming up with a delivery method.
We already know. There are four main mechanisms for horizontal gene transfer:
1. Free DNA uptake 2. Phage transfer 3. Conjugation 4. GTA
Preventing any of these is near impossible.
We have however had some success in using phage therapy against some MDRs.
Might be a bit rough on gut bacteria, though...
From what I have read and experienced firsthand, you are far better off strengthening your gut flora, not undermining them.