Neurological manipulation to manage inflammatory condition may have a promising future, and may be a good avenue to pursue for some patients (like people not responding to immunomodulation). At a conference I overheard of botox injection reducing psoriasis plaques in otherwise unresponsive patients (just hearsay), and it is known that patients with onset of types of neurologic damage (e.g. Parkinsons) have increased risk of another inflammation-related condition seborrheic dermatitis (just correlation). Teasing apart causal mechanisms at work could be quite a task.