He has abandonded mathematics. I don't know what he works on now.
Currently he mentions that he has everything he wants and doesn't want to be paraded like an animal in the zoo for everyone to see. He doesn't want money and honors.
What has alienated him from mathematics is others dishonesty. Read the "Manifold Destiny" article from New Yorker by Sylvia Nasar and David Gruber (http://www.newyorker.com/archive/2006/08/28/060828fa_fact2). In there you'll find a reference to Shing-Tung Yau. Quote from the article:
As for Yau, Perelman said, “I can’t say I’m outraged. Other people do worse. Of course, there are many mathematicians who are more or less honest. But almost all of them are conformists. They are more or less honest, but they tolerate those who are not honest.”