It's not their fault! As Heather Bresch and Martin Shkreli have been telling us, it's their fiduciary duty to their shareholders to manipulate government regulation in order to reap as much profit as possible.
i.e. sunlight is the best disinfectant, PR feedback loop, etc, etc...
Sidenote: If you research more, Shkreli does have reasons for the price hike (research). He says that 60-70% of Daraprim is given for free and no one is dying from lack of access. I don't know how true it is, but he doesn't seem like a villain.
That's his PR pitch. Shkreli says he's giving drugs away for free, but really he's not. What's actually happening is his company makes a tax-deductible donation to an org that covers patients' co-pays, and leaves health insurers/Medicaid to cover the other 80% of the cost. Covering the co-pay keeps patients on the drug longer so his company can milk more money from insurers. It's a great moneymaking scheme.
Shkreli didn't think of this himself, many drug companies do the same. Like you mentioned, I don't think he's a villain for doing this, he's just a smart guy who saw how drug companies abuse the system and tried to copy them.
There's a lot more on this topic in this Bloomberg article http://www.bloomberg.com/news/articles/2016-05-19/the-real-r...
Also, the patients are hurt. Who pays for these drug price hikes? That cost is paid by patients in their higher insurance premiums and American taxpayers in their dollars to Medicaid. Companies that do what Shkreli did make healthcare more expensive for all Americans.
The underlying theme is that there are seriously perverse incentives issues in American healthcare that need to be resolved. Until then, some people will make a lot of money.