Firstly, on a personal note, I must say getting heavily downvoted on a factual statement and not an opinion is a new and confusing experience for me.

My comparisons were made several years ago using LAME 320 CBR, LAME VBR, OGG, lossless (WAV) 16bit 44.1kHz and lossless (WAV) 16bit 48kHz. I believe at least most professional musicians and sound engineers would be able to identify the difference between all of these; while they might not always be "worse", their sonic character is certainly different.