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I'd say one of the more exciting possibilities is helium-free NMR & MRI.

The high temperature stuff is still very sensitive to strong changing magnetic fields, so I'm not holding my breath for MRI.

But don't ignore improvements in low temperature superconductors engineering:

...I also believe that GE is working on a MRI using liquid hydrogen as the cryogen.

> I also believe that GE is working on a MRI using liquid hydrogen as the cryogen.

What could possibly go wrong?

"This asphyxiant gas is expensive and dangerous if it leaks. What should we do?"

"Well... we could replace the asphyxiant with an explosive gas?"

"..."

Not much. Liquid hydrogen could leak a little. Then it could burn a little. In the liquid form its 100's of degrees away from burning.