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Since native modules can't be used with this, what is the difference between this and, say, Appcelerator Titanium?

I think Appcelerator Titanium is more comparable to React Native than to Exponent. Here's a post by Brent about the differences between Exponent and React Native: http://stackoverflow.com/questions/39170622/what-is-the-diff.... You can join us on Slack if you want to discuss more! https://slack.exponentjs.com/

(I work on Exponent)