This is the big problem with Blender. The interface lacks an artist's eye for what to prioritise and group, what to hide away in a menu with what and what to have out in the open for easy access. It's an incredible piece of software, but it has the steepest learning curve out of everything because of this. And 3D in general is the steepest learning curve of all without having to fight the gui.

ZBrush is similar at the opposite end of the spectrum, with it's own language and gui priorities, but at least it's entirely customisable.