If Adobe supported linux, I could almost do my entire job without Windows. The only missing piece would be support for Exchange-based email. But for now I've got two machines, 3 monitors, and make great use of Synergy.
I feel like a luddite though because I use and love linux, but have never taken the time to learn and use the workspaces feature. It would probably be cheaper to learn it than to keep throwing monitors at my space issues :P