We are talking about common desktop PCs with more or less standard set of packages, not about server machines. I seriously doubt there are any breakages there.
I've never seen that happen in native GNU/Linux applications, though. I guess it might be related to the XUL stuff in Firefox.
But given that Firefox (and Chrome/ium) are memory hogs that eventually get OOM killed, you need to restart them periodically anyway, so it might not make a big difference if the OS does auto-updates in the background.
[0] http://www.telegraph.co.uk/technology/2016/08/25/windows-10-...