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I've been running ARM machines for years (since before the Raspberry Pi was cool).

These days I have no trouble running most common Linux desktop software on ARM. Even Docker works (with ARM binaries inside the containers, of course).

I'd say the only sticking points would be graphics/assembly/hardware-related stuff, and all of them surmountable.

I tried setting up a Linux server on a Linksys WRT router a dozen or so years ago, but back then I did notice the open-source ARM binaries weren't widespread. I can't remember exactly for what but I believe I gave up compiling some downloaded code after a while for what I wanted to do.

The user land is based on FreeBSD, which has run on arm for years.

iOS NoUI builds have separate kexts and the full Darwin CLI tools, including the Clang compiler itself.