Currently, I see about 30 HN applicants per month. We interview roughly 30%. The rest are unqualified, demonstrated no understanding of or interest in what we do, and/or were spamming their resume.
These get interviews:
* Strong candidates who did their homework (this is always the best)
* Strong candidates with minimal or lightly tailored emails
* Borderline candidates who did their homework
These get polite rejections: * Borderline candidates who did no homework
* Unqualified candidates
These get ignored: * Candidates who send blatantly templated emails
* Candidates who apply via "email blasts" (e.g., BCC all recipients; send via an email campaign tool)
I prefer to see both understanding of and interest in the role. Tell me why you're a fit and why you want to work here. A few sentences will suffice. Doing so: 1) improves the probability of an interview; and 2) for me, practically guarantees you a response.